The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface proteins essential for the adaptive immune system.

HLA研究中，模拟免疫反应激活的过程，就要经过 蛋白酶体对抗原（蛋白）的剪切预测 、肽段转运、 肽段和MHC-I结合亲和力预测 以及 T细胞识别预测 等几个重要步骤。 一般可以采用滑动窗口（sliding windows）的方法把可能的肽段都提取出来，MHC结合亲和力预测由软件实现（但效果各有说法，最好多重比较筛选， 软件对比），更严谨的可以用抗原实验来验证（制造目标肽段，做实验查看与MHC的结合情况）。 HLA配型也叫移植配型，HLA基因座位点具有高度多态性，完 …

View and compare the structure of class I and class II alleles across species. Full details of all the species included in IPD-MHC and their official designations are available in the taxonomy page. If you are working on MHC nomenclature and your species is not represented, please contact the Comparitive MHC Nomenclature Committee.

2013年7月18日 · The Major Histocompatibility complex (MHC) system known as the human leukocyte antigen (HLA) in humans is located on the short arm of chromosome 6 (6p21.3) and contains the most polymorphic gene cluster of the entire human genome.

The particular combination of MHC alleles found on a single chromosome is known as an MHC haplotype. Expression of MHC alleles is codominant, with the protein products of both the alleles at a locus being expressed in the cell, and both gene products being able to …

2021年10月18日 · Here, we connected HLA alleles with binding motifs via our deep learning-based framework, MHCfovea. MHCfovea expanded the knowledge of MHC-I-binding motifs from 150 to 13,008 alleles.

Major histocompatibility complex (MHC) genes code for cell surface proteins that facilitate an organism's immune response to pathogens as well as its ability to avoid attacking its own cells. These genes have maintained an unusually high level of allelic diversity throughout time and throughout different populations.

2017年4月27日 · The large number of MHC alleles means each individual has a nearly unique set of peptide-presenting allotypic MHC molecules, and each MHC allotype confers the ability to bind different peptides. The MHC genes are classified into five subregions from the telomeric to the centromeric end: the extended class I, class I, class III, class II, and ...

2023年1月3日 · Major histocompatibility complex (MHC) class I glycoproteins present selected peptides or antigens to CD8 + T cells that control the cytotoxic immune response. The MHC class I genes are among the most polymorphic loci in the vertebrate genome, with more than twenty thousand alleles known in humans.

IPD-MHC alleles. The Allele Query Tool provides advanced query interface allowing users to generate customizable queries to the IPD-MHC database. This is available via a web interface or a REST API. Please see our help pages for documentation on the use of this tool. The query tab allows to quick search for alleles by name.