12 小时之前 · 为探究心肌梗死（mi）中 il-6 来源及调控机制，研究发现 t 细胞衍生腺苷经 a 2b 受体调节成纤维细胞 il-6，为治疗提供新靶点。 心肌梗死（Myocardial Infarction，MI），这个隐匿在健康背后的 “杀手”，正悄无声息地威胁着全球无数人的生命。

CONCLUSIONS: IL-6 in acute MI shows a curved time course and is highly correlated to CRP. It peaks on days 1 and 2 and remains elevated even after 12 weeks. Increased IL-6 levels after hospital discharge are associated with HF and depressed LVF.

2023年6月1日 · Plasma IL-6 is elevated after myocardial infarction (MI) and is associated with increased morbidity and mortality. Which cardiac cell type preferentially contributes to IL-6 expression and how its production is regulated are largely unknown. Here, we studied the cellular source and purinergic regula …

2022年4月30日 · We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in ST-elevation myocardial infarction (STEMI). However, the mechanisms for this effect are not clear.

2021年4月1日 · Genome-wide association studies demonstrate that random allocation of alleles that control IL-6 signaling associate with lifelong increased cardiovascular risk (4), while phenome-wide association studies link IL-6 to the development of peripheral arterial disease, aortic aneurysm, and stroke (5).

Interleukin (IL)-6 is an emerging therapeutic target in myocardial infarction (MI). IL-6 has 2 distinct signaling pathways: trans-signaling, which mediates inflammation, and classic signaling, which also has anti-inflammatory effects.

2021年4月27日 · A new randomized clinical trial now shows that tocilizumab, a monoclonal antibody that inhibits IL-6 signalling by binding to the IL-6 receptor, increases myocardial salvage in patients with...

Studies from myocardial infarction show how short-term IL6 signaling can protect and preserve the heart tissue in response to acute damage, where long term IL6 signaling or an over-production of IL6R protein plays a causal role in cardiovascular disease.

2023年3月21日 · Plasma IL-6 is elevated after myocardial infarction (MI) and is associated with increased morbidity and mortality. Which cardiac cell type preferentially contributes to IL-6 expression and how its production is regulated are largely unknown. Here, we studied the cellular source and purinergic regulation of IL-6 formation in a murine MI model.

2018年11月15日 · These findings suggest that IL-6 is a potential target molecule for the prevention and amelioration of MI. A meta-analysis of observational studies has shown a 1.5 to 2.0 times increased risk of cardiovascular morbidity and mortality in RA patients, while several cohort studies reported a decreased cardiovascular risk using tumor necrosis ...