MK Airlines Flight 1602 was an MK Airlines Boeing 747-200F cargo flight on a flight from Halifax Stanfield International Airport, Nova Scotia, Canada, to Zaragoza Airport, Spain. It crashed on take-off in 2004, killing the crew of 7.

Ubrogepant (MK-1602) is an orally active calcitonin gene-related peptide receptor (CGRP) antagonist with potential for use in acute migraine.

At 00:03 local time MK Airlines flight 1602 departed Windsor Locks-Bradley International Airport (BDL) for a flight to Zaragoza, Spain with a cargo of lawn tractors. An intermediate stop was made at Halifax (YHZ), where the aircraft landed at 02:12 local time.

Ubrogepant, also known as MK-1602, was discovered by scientists at Merck. [ 9 ] The effectiveness of ubrogepant for the acute treatment of migraine was demonstrated in two randomized, double-blind, placebo-controlled trials. [ 6 ]

2017年11月7日 · Ubrogepant (MK-1602), an oral calcitonin gene-related peptide (CGRP) antagonist, is in phase III clinical development at Allergan for the acute treatment of migraine attacks. In August 2015, the product was licensed to Allergan by Merck, for the development and marketing worldwide for the treatment of migraine.

We applied this strategy for another late-stage clinical program: ubrogepant (MK-1602), a novel oral calcitonin gene-related peptide receptor antagonist for acute treatment of migraine. At the time of implementation, ubrogepant was entering phase 2 development.

2019年4月30日 · 艾尔建于2018年10月宣布已完成Ubrogepant（MK-1602）用于偏头痛急性治疗的2项临床研究，并获得了积极的安全性和耐受性数据。 其他正在进行临床研究的小分子拮抗剂项目包括：勃林格殷格翰的BI44370TA（400mg，口服）Ⅱ期试验显示效果与依立曲坦相当，且具有良好的耐受性，但该药是否有肝脏毒性尚不清楚；百时美施贵宝的BMS-927711（75-300mg，口服）Ⅱ期试验表现良好，目前已进入Ⅲ期临床研究。 单克隆抗体. 后来者居上，2018年上市三个 …

2022年5月28日 · Despite the destruction of the aircraft’s cockpit voice recorder, investigators were able to piece together a probable series of errors, made in the dead of night on a Windows laptop behind the...

中文名:乌布吉泮,英文名:Ubrogepant,CAS:1374248-77-7,化学式:C29H26F3N5O3,分子量:549.54,密度:1.45±0.1 g/cm3 (Predicted),沸点:729.4±60.0 °C (Predicted),MSDS.

Ubrogepant (MK-1602) 是一种新型的，具有口服活性的降钙素基因相关肽受体 (CGRP) 拮抗剂，结构中含有螺环基团，可用于偏头痛的相关研究。 立即从AbMole中国订购高品质CGRP Receptor抑制剂Ubrogepant ！