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MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D 4 (LTD 4) receptor antagonist, with K i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release.

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MK571是一种具有口服活性的、选择性 半胱氨酰白三烯受体CysLT1 的拮抗剂。 L-660,711 (MK-571)在豚鼠肺中抑制 [3H]LTD4的结合，Ki值为0.22±0.15 nM (n=35)，在人类肺部抑制 [3H]LTD4的结合，Ki值为2.1±1.8 nM (n=29)。 L660,711对 [3H]LTC4的结合活性较低或没有活性，在豚鼠肺部IC50为23±11 μM (n=16)、在人类肺部中IC50为32 μM (n=1) [1]。 将细胞以1×10 3 /孔的密度接种于96孔板，在37℃、5% CO2的细胞培养箱中培养72小时，让MRP1的信使RNA受到抑制。 …

mk-571（l-660711）是一种口服活性、强效和选择性竞争性白三烯 d4（ltd4）受体拮抗剂，在豚鼠和人肺膜上的 ki 值分别为 0.22 和 2.1 nm。 MK-571 还是一种 MRP4 和 ABCC1（MRP1）抑制剂。

MK571 (L660711) 是一种具有口服活性的、选择性半胱氨酰白三烯受体CysLT1的拮抗剂。 L-660,711 (MK-571)在豚鼠肺中抑制 [3H]LTD4的结合，Ki值为0.22±0.15 nM (n=35)，在人类肺部抑制 [3H]LTD4的结合，Ki值为2.1±1.8 nM (n=29)。 L660,711对 [3H]LTC4的结合活性较低或没有活性，在豚鼠肺部IC50为23±11 μM (n=16)、在人类肺部中IC50为32 μM (n=1)。 健康年轻人对MK-571耐受良好。 在口服后，MK-571被迅速吸收。 在给药后1.1-1.5小时后血药浓度达到峰值。

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MK 571 effectively blocks LTD4 activation of recombinant human and mouse CysLT1 receptors but is ineffective at blocking LTC4 or LTD4 activation of the recombinant human or murine CysLT2 receptors. It potentially inhibits MRP1 and has been shown to …

Назначение: Oil seal, Артикул: (577171 / 114140N, 114140N,), Размер: 142.88*165.1*12.7, Примечание: Type по SOG: 104 Стандарт: ГОСТ 8752-79 / DIN 3760 Type: 2.2/2.1 - АS, Цена: 8.15 €