In molecular biology, the sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells.

There are 27 Toyota Supra - 4th Gen (A80) for sale right now - Follow the Market and get notified with new listings and sale prices.

Find great deals on the mk4 Toyota Supra with CarGurus. The fourth generation A80 Supra was on sale from 1993 to 2002, and remains one of the most sought-after cars of its era. Act fast, as you’ll be furious if you miss out. Find the best deals on classic MK4 Supras ranging from project car to showroom condition.

SUR1 is an ATP-binding cassette (ABC) transporter with a novel function. In contrast to other ABC proteins, it serves as the regulatory subunit of an ion channel. The ATP-sensitive (KATP) channel is an octameric complex of four pore-forming Kir6.2 ...

La Toyota Supra (ou トヨタスープラ en japonais) est une voiture de grand tourisme produite par le constructeur automobile japonais Toyota, de 1979 jusqu'en 2002, puis à partir de 2019. La voiture a connu quatre générations successives et une cinquième plus tardivement, communément appelées MK1, MK2, MK3, MK4 et MK5 (MK étant l'abréviation de mark).

2021年10月14日 · 来自墨西哥国立神经病学和神经科学研究所的Penélope Aguilera团队认为在三磷酸腺苷降低的脑病理中观察到65 kDa SUR1蛋白，即可在代谢应激条件下以降低三磷酸腺苷浓度来调节离子通道的活性。 该证据与在细胞培养中进行的研究相吻合，其中对磺酰脲具有高（140 kDa）或低亲和力（65 kDa）的SUR1变体的表达在很大程度上取决于培养条件。 在高葡萄糖（25 mM）下，细胞同时表达两种磺酰脲受体，与格列本脲的亲和力高（Kd = 1 nM）和亲和力 …

K ATP channels (e.g., SUR1-KIR6.2) or SUR1-TRPM4 channels have opposite effects on membrane potential. Therefore, edema formation is mediated by SUR1-TRPM4 activation and clearly associated to a high morbidity and mortality in large hemispheric infarction and severe traumatic brain injury (TBI) but also with other central nervous system ...

2013年2月1日 · The sulfonylurea receptor 1 (Sur1)-NC (Ca-ATP) channel plays a central role in necrotic cell death in central nervous system (CNS) injury, including ischemic stroke, and traumatic brain and spinal cord injury. Here, we show that Sur1-NC (Ca-ATP) channels are formed by co-assembly of Sur1 and transient …

It associates with sulfonylurea receptor 1 (Sur1) to form Sur1-Trpm4 channels, which have critical roles in cytotoxic edema, cell death, blood-brain barrier breakdown, and vasogenic edema. We examined Trpm4 expression in postmortem brain specimens from 15 patients who died within the first 31 days of the onset of focal cerebral ischemia.

1999年12月6日 · Prominent members include the sulfonylurea receptor (SUR1) and the multidrug transporter (MDR1). SUR1 is a subunit of the pancreatic β-cell K ATP channel and plays a key role in the regulation of glucose-induced insulin secretion. SUR1 binds ATP at NBF1, and ADP at NBF2 and the two NBFs work cooperatively.