MAP2K4 - Wikipedia
Dual-specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene. [5] MAP2K4 encodes a dual-specificity kinase that belongs to …
Mitogen-activated protein kinase kinase 4 (MKK4) - PubMed
The Mitogen-Activated Protein Kinase Kinase 4 (MKK4), a member of the MAP kinase kinase family, directly phosphorylates and activates the c-Jun NH2-terminal kinases (JNK), in …
MAP2K4 Gene - GeneCards | MP2K4 Protein | MP2K4 Antibody
2024年12月25日 · MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4) is a Protein Coding gene. Diseases associated with MAP2K4 include Colorectal Cancer and Breast Cancer. …
First-in-class MKK4 inhibitors enhance liver ... - ScienceDirect
2024年3月28日 · MKK4 inhibition increased hepatocyte proliferation and liver regeneration upon hepatectomy in murine and porcine models and also revealed antisteatotic efficacy (mouse …
首创新药MKK4抑制剂（HRX215）可显著增强肝再生并预防肝衰竭
近日，来自德国图宾根大学医院的 Lars Zender 团队在 Cell 杂志上发表一篇题为 First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure 的文章，他们在此 报告了 …
First-in-class MKK4 inhibitors enhance liver regeneration and …
2024年3月28日 · Here, we report on the structure-based development and characterization (nuclear magnetic resonance [NMR] spectroscopy) of first-in-class small molecule inhibitors of …
MKK4 Inhibitors-Recent Development Status and Therapeutic …
2023年4月19日 · MKK4 (mitogen-activated protein kinase kinase 4; also referred to as MEK4) is a dual-specificity protein kinase that phosphorylates and regulates both JNK (c-Jun N-terminal …
MKK4 抑制剂——近期发展状况和治疗潜力 ... - X-MOL
MKK4（丝裂原活化蛋白激酶激酶 4；也称为 MEK4）是一种双特异性蛋白激酶，可磷酸化和调节 JNK（c-Jun N 末端激酶）和 p38 MAPK（p38 丝裂原活化蛋白激酶）信号通路，因此对细胞的 …
【Cell 】全新靶点MKK4 抑制剂已进入Ⅰ期临床试验，风险与机遇 …
2024年3月17日 · 德国图宾根大学 的 Lars Zender 团队在肝再生领域深耕十余年，2013 年曾在 Cell 报道通过体内 RNAi 筛选鉴定出丝裂原活化蛋白激酶激酶 4（MKK4）是肝细胞再生的关键 …
MKK4 Inhibitors—Recent Development Status and Therapeutic
2023年4月19日 · MKK4 (mitogen-activated protein kinase kinase 4; also referred to as MEK4) is a dual-specificity protein kinase that phosphorylates and regulates both JNK (c-Jun N-terminal …