Dual-specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene. [5] MAP2K4 encodes a dual-specificity kinase that belongs to the Ser/Thr protein kinase family. MAP2K4 phosphorylates MAP kinases in response to various environmental stresses or mitogenic stimuli.

The Mitogen-Activated Protein Kinase Kinase 4 (MKK4), a member of the MAP kinase kinase family, directly phosphorylates and activates the c-Jun NH2-terminal kinases (JNK), in response to cellular stresses and proinflammatory cytokines.

2024年12月25日 · MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4) is a Protein Coding gene. Diseases associated with MAP2K4 include Colorectal Cancer and Breast Cancer. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Prolactin Signaling.

2024年3月28日 · MKK4 inhibition increased hepatocyte proliferation and liver regeneration upon hepatectomy in murine and porcine models and also revealed antisteatotic efficacy (mouse models of ASH and NASH), as well as antifibrotic efficacy in a CCl 4 liver damage mouse model. We are convinced that the observed antisteatotic and antifibrotic activity provides ...

近日，来自德国图宾根大学医院的 Lars Zender 团队在 Cell 杂志上发表一篇题为 First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure 的文章，他们在此 报告了首创新药MKK4小分子抑制剂HRX215的开发及功能表征，证明该药可预防肝切除术后肝衰竭 （PHLF ...

2024年3月28日 · Here, we report on the structure-based development and characterization (nuclear magnetic resonance [NMR] spectroscopy) of first-in-class small molecule inhibitors of the dual-specificity kinase MKK4 (MKK4i).

2023年4月19日 · MKK4 (mitogen-activated protein kinase kinase 4; also referred to as MEK4) is a dual-specificity protein kinase that phosphorylates and regulates both JNK (c-Jun N-terminal kinase) and p38 MAPK (p38 mitogen-activated protein kinase) signaling pathways and therefore has a great impact on cell prolife …

MKK4（丝裂原活化蛋白激酶激酶 4；也称为 MEK4）是一种双特异性蛋白激酶，可磷酸化和调节 JNK（c-Jun N 末端激酶）和 p38 MAPK（p38 丝裂原活化蛋白激酶）信号通路，因此对细胞的增殖、分化和凋亡有很大的影响。

2024年3月17日 · 德国图宾根大学 的 Lars Zender 团队在肝再生领域深耕十余年，2013 年曾在 Cell 报道通过体内 RNAi 筛选鉴定出丝裂原活化蛋白激酶激酶 4（MKK4）是肝细胞再生的关键调控因子。

2023年4月19日 · MKK4 (mitogen-activated protein kinase kinase 4; also referred to as MEK4) is a dual-specificity protein kinase that phosphorylates and regulates both JNK (c-Jun N-terminal kinase) and p38 MAPK (p38 mitogen-activated protein kinase) signaling pathways and therefore has a great impact on cell proliferation, differentiation and apoptosis.