移植的 cd41 + lsk 细胞在体内分化为所有骨髓和淋巴细胞类型，并在体外和体内产生单能巨核细胞祖细胞 (mkp)、成熟巨核细胞和血小板，比 flt3 + cd41 - lsk 细胞更有效。

2023年7月1日 · The authors reported that this new progenitor cell type, termed lymphoid-primed multipotent progenitor (LMPP), has reduced self-renewal capacity but can give rise to both lymphoid and myeloid lineages. These findings have been recapitulated in both mouse and human models [25, 62, 90, 91].

2019年6月14日 · In this model, HSCs first differentiate into MPP1/ST-HSC, then give rise to MPP2, MPP3 and MPP4 (LMPP). MPP2 can generate pre MegE, and subsequently, pre MegE gives rise to platelets through MkP or produce erythrocytes through Pre CFU-E. MPP3 mostly give rise to granulocyte and monocyte lineages, and MPP4 (LMPP) mainly contribute to …

2016年3月10日 · Such studies would have allowed a more detailed understanding of the relationships between CD41 + LSK cells and previously defined LT-HSC, ST-HSC, and LMPP populations. In addition, the relationship between the stress-induced CD41 + CD42b + MkP and other previously identified MkP populations were not explored.

2020年10月19日 · Through generation of Dach1 –GFP reporter mice, we identify a transcriptionally and functionally unique Dach1 –GFP − subpopulation within LMPPs with lymphoid potential with low to negligible...

2024年3月6日 · 首先，该研究开发了可以区分直接（direct）和逐步（stepwise）造血分化路径的谱系示踪系统（CD48-Dre），实现了对逐步分化路径上的RPs的高效且特异性的标记（图A）。 同时，研究组构建了Rosa26loxp-STOP-loxp-rox-loxp-ZsGreen-STOP-rox-tdTomato（R26ZT1）报告小鼠，利用此小鼠将广泛表达的Ubc-creER与CD48-Dre正交重组，实现了对CD48-Dre+细胞的诱导性示踪（图B、C），绘制了不同谱系各个层级造血细胞的更替曲线，结果提示逐步分化 …

2007年10月15日 · The LMPP contains PU.1 + GMLPs and RAG1 + ELPs, and these progenitor populations might represent continuous developmental steps from the MPP to the lymphoid-committed CLP. CMP, common myeloid ...

2013年8月29日 · MPPs produce Flt3 + CD34 + KSL lymphoid-primed multipotent progenitors (LMPPs) (Adolfsson et al., 2005). MPPs and LMPPs are considered to be multipotent progenitor cells with limited or no self-renewal activity, that is, allowing only short-term (up to 8 weeks) multilineage repopulation.

Single-cell RNA sequencing of >120,000 hematopoietic stem and progenitor cells demonstrated Mk-biased hematopoiesis across clinical and molecular MF subgroups. Mk progenitors were heterogeneous, with distinct expression of inflammatory mediators.

2007年6月22日 · In summary, the currently available data strongly suggest that the MPP go through either the CMP or the LMPP (or GMLP) stages to give rise to myeloid and lymphoid lineages (Figure 1 A, right). The CLP might be downstream of the LMPP (or GMLP).