2017年5月11日 · Alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonists can prevent glutamate-induced excitotoxicity in cultured retinal ganglion cells (RGCs). However, the …

2023年3月12日 · In this study, PNU-282987 activated α7-nAChRs in endothelial cells, resulting in the perinuclear accumulation of eNOS and increased NO production, which was inhibited by …

目的:阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)是指睡眠过程中反复出现上呼吸道阻塞的一种睡眠障碍,可导致血氧饱和度反复降低,睡眠片段化,交感神经自主活动增强.OSA与全身多 …

To validate the specific effects of α7nAchR agonists, subacute MPTP mice were pretreated with methyllycaconitine (MLA), a selective α7nAchR antagonist before GTS-21 administration. …

Results: α7nAChR stimulation improved neurological outcome and reduced brain edema at 24 and 72 hours after surgery (P<0.05 compared with vehicle). Furthermore, PHA-543613 …

2022年6月22日 · PNU-282987 treatment remarkably improved systolic function by increasing LVEF, LVFS and IVS (d, s) at 7 and 30 days after ICH. However, MLA could reverse this effect …

2015年3月26日 · Our results showed that MLA (Fig. 3A1–C1) or DhβE (Fig. 3A2–C2) partially reduced nicotinic enhancement on γ power, but a combination of both antagonists blocked the …

To validate the specific effects of α7nAchR agonists, subacute MPTP mice were pretreated with methyllycaconitine (MLA), a selective α7nAchR antagonist before GTS-21 administration. …

PNU-282987 (free base) (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a K i of 27 nM. PNU-282987 has …

2021年1月25日 · We found that PNU-282987 significantly improved the motor deficits induced by 6-OHDA, reduced the loss of TH in the SN, suppressed the overactivation of GFAP+ cells and …