MLK3英文全名为Mixed Lineage Kinase 3 ，中文名为混合谱系酶3，是一个分子量为97kDa的丝氨酸/苏氨酸蛋白激酶，属 丝裂原活化蛋白激酶 (MAP3K)。 MLK3由一个SH3结构域，一个激酶结构域，双重 亮氨酸拉链，一个CDC42/Rac互动结合模体（CRIB）和一个富含脯氨酸的C-端组成。 MLK3能通过亮氨酸拉链二聚体化从而激活其下游信号。 SH3结构域能在亮氨酸拉链和CRIB结构之间结合一个脯氨酸残基，通过这种形式，MLK3处于自身抑制的状态。 Rho家族成 …

Martin Luther King III (born October 23, 1957) is an American human rights activist, philanthropist, and an advocate. The elder son of civil rights leaders Martin Luther King Jr. and Coretta Scott King, he served as the fourth president of the Southern Christian Leadership Conference from …

Mixed lineage kinase 3 (MLK3) is a serine/threonine kinase family member of mitogen activated protein kinase kinase kinases (MAP3Ks). MLK3 has been implicated in the regulation of tumor cell proliferation, differentiation, migration, invasion, and apoptosis depending on the cellular contexts.

2022年10月1日 · Mixed lineage kinase 3 (MLK3) is a serine/threonine kinase family member of mitogen activated protein kinase kinase kinases (MAP3Ks). MLK3 has been implicated in the regulation of tumor cell proliferation, differentiation, migration, invasion, and apoptosis depending on the cellular contexts.

Mixed-lineage protein kinase 3 (MLK3) is a member of the mitogen-activated protein (MAP) kinase kinase kinase group that has been implicated in multiple signaling cascades, including the NF-κB pathway and the extracellular signal-regulated kinase, c-Jun NH 2 -terminal kinase (JNK), and p38 MAP kinase pathways.

2023年9月5日 · In this review, we will focus on the role of MLK3 in neuron-related cell death processes, neurodegenerative diseases, and the potential advantages of targeting this kinase through pharmacological modulation for neuroprotective treatment. 1. Introduction. Protein kinases play crucial roles in several biological processes.

2024年6月10日 · Mixed Lineage Kinase 3 (MLK3) is a key regulator of liver diseases, although its role in HCC remains unclear. Analysis of TCGA databases suggested elevated MAP3K11...

2020年4月7日 · Mixed lineage kinase 3 (MLK3), also known as MAP3K11, was initially identified in a megakaryocytic cell line and is an emerging therapeutic target in cancer, yet its role in immune cells is not known. Here, we report that loss or pharmacological inhibition of MLK3 promotes activation and cytotoxicit …

2002年9月1日 · The MLK3 SH3 domain seems to bind intramolecularly to a region between the leucine zipper and the CRIB motif, and mutation of the single proline here prevents SH3 binding and increases kinase...

Recent advances have shown that MLK3 plays a role in cancer cell survival, migration, drug resistance, cell death, and tumor immunity. This review describes how MLK3 regulates different MAPK pathways, cancer cell growth and survival, apoptosis, and host’s immunity.