2004年4月15日 · MLL binds to promoters (and probably other sequences) of Hox genes such as Hoxa7 and Hoxa9 to maintain their expression. 1,2 These Hox proteins regulate hematopoiesis and are normally expressed only in early hematopoietic progenitors.

mll调节有造血调节作用的hox基因，也是mll融合蛋白导致白血病的重要机制。基因敲除实验提示mll作用于造血干细胞向定向祖细胞发育和扩增的早期造血阶段。

Translocations that involve the mixed lineage leukaemia (MLL) gene identify a unique group of acute leukaemias, and often predict a poor prognosis. The MLL gene encodes a DNA-binding...

Aggressive leukemias arise in both children and adults as a result of rearrangements to the mixed-lineage leukemia gene (MLL) located on chromosome 11q23. MLL encodes a large histone methyltransferase that directly binds DNA and positively regulates gene transcription, including homeobox (HOX) genes …

2016年2月8日 · In this report, we found that both mutated DNMT3A and MLL fusions deregulated HOX and MEIS1 gene expression by diminishing the recruitment of BMI1 to their promoters, thus at least partially ...

2021年4月6日 · Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master regulator for transcription of important genes (e.g., Hox genes) for embryonic development and hematopoiesis.

MLL, the human homolog of Drosophila trithorax, maintains Hox gene expression in mammalian embryos and is rearranged in human leukemias resulting in Hox gene deregulation. How MLL or MLL fusion proteins regulate gene expression remains obscure. We show that MLL regulates target Hox gene expression t …

MLL regulates Hox gene expression through direct promoter binding and histone modification. MLL rearrangements occurring in leukemia include MLL fusion genes, partial tandem duplications of MLL and MLL amplification. MLL fusions and amplification upregulate Hox expression

2007年12月4日 · Fusion of the mixed lineage leukemia protein (MLL) to one of over 50 different translocation partners converts it into a potent leukemogenic oncoprotein. The resulting fusion proteins transform primarily through upregulation of A-cluster Hox genes, including Hoxa9 and the Hox cofactor Meis1.

MLL (for mixed-lineage leukemia) is a proto-oncogene that is mutated in a variety of human leukemias. Its product, a homolog of Drosophila melanogaster trithorax, displays intrinsic histone methyltransferase activity and functions genetically to maintain embryonic Hox gene expression. Here we report …

Aggressive leukemias arise in both children and adults as a result of rearrangements to the Mixed Lineage Leukemia (MLL) gene located on chromosome 11q23. The MLL gene encodes a large histone methyltransferase that directly binds and positively regulates gene …

2011年11月18日 · AF9 是最常见的 MLL 融合伙伴之一，在 HOX 基因的正常调节中发挥作用。 AF9 还被证明与多种转录调节因子相互作用，包括募集和激活 P-TEFb 的 AF4 家族蛋白，表明在 HOX 基因座转录延伸的调节中起关键作用。 AF9 调节正常转录并导致 MLL-AF9 白血病转录失调的机制知之甚少。 我们最近表明保留在 MLL 融合蛋白中的 AF9 ANC1 同源域（AHD）本质上是无序的，即它本身是非结构化的，并通过耦合折叠和绑定招募AF4家族成员。 为了进一步了解这 …

MLL is homologous to Drosophila Trithorax, a positive regulator of transcription during development. The best understood target genes of MLL are the clustered homeobox or Hox genes, which are transcription factors that are involved in …

2009年3月12日 · We demonstrate that HOXA9 depletion in 17 human AML/ALL cell lines (7 MLL -rearranged, 10 MLL -germline) induces proliferation arrest and apoptosis specifically in MLL -rearranged cells (P = .007). Similarly, assessment of primary AMLs demonstrated that HOXA9 suppression induces apoptosis to a greater extent in MLL -rearranged samples (P = .01).

Fusion of the mixed lineage leukemia protein (MLL) to one of over 50 different translocation partners converts it into a potent leukemogenic oncoprotein. The resulting fusion proteins transform primarily through upregulation of A-cluster Hox genes, including Hoxa9 and …

2014年1月1日 · Next to ensuring proper HOX expression, MLL is also involved in E2F-mediated transcription of Cyclin genes that are essential for cell cycle initiation and progression. Concomitant with the periodic activity of these genes, MLL shows a parallel cyclic expression pattern throughout the cell cycle.

MLL (for mixed-lineage leukemia) is a proto-oncogene that is mutated in a variety of human leukemias. Its product, a homolog of Drosophila melanogaster trithorax, displays intrinsic histone methyltransferase activity and functions genetically to maintain embryonic Hox gene expression. Here we report the biochemical purification of MLL and ...

2010年6月28日 · In MOZ (MOnocytic leukemia Zinc-finger protein)/CBP- or mixed lineage leukemia (MLL)-rearranged leukemias, abnormal levels of HOX transcription factors have been found to be critical for...

Increased and sustained Hox expression is found in a subset of leukemia with chromosomal translocations involving the MLL gene. 1–3 This observation suggested that the MLL gene product (Mixed Lineage Leukemia or Mll protein) might be involved in HOX regulation.

2004年4月15日 · The current study was undertaken using a genetic approach with Hox-deficient primary hematopoietic progenitors, together with retroviral transduction/transplantation assays, to molecularly dissect the functional requirements of individual Hox genes for in vitro and in vivo MLL–mediated leukemogenic transformation.