Murine Models of Acute Myeloid Leukaemia - PMC
Here we review the most important AML mouse models of each category, briefly describe their advantages and limitations and show how they have contributed to our understanding of the …
Protocol to establish a stable MLL-AF9_AML mouse model
2022年9月16日 · Acute myeloid leukemia (AML) is one of the most common and fatal forms of hematopoietic malignancies. Here, we describe a mouse MLL-AF9_AML model to investigate …
Modeling human MLL-AF9 translocated acute myeloid leukemia …
2016年10月26日 · To circumvent the genetic heterogeneity of AML patient cohorts, we have developed a model system, driven by the MLL-AF9 (MA9) oncogene, to generate multiple …
MLL-AF9 initiates transformation from fast-proliferating ... - Nature
2019年12月18日 · By tracking de novo transformation from normal hematopoietic progenitors expressing an acute myeloid leukemia (AML) oncogene MLL-AF9, we reveal that the cell cycle …
Animal models of acute lymphoblastic leukemia ... - ScienceDirect
2022年4月1日 · In this article we review ALL animal models’ progression, their roles in revealing the pathogenesis of ALL and drug development. Additionally, we mainly focus on the mouse …
Protocol to establish a stable MLL-AF9 _AML mouse model
2022年7月18日 · Acute myeloid leukemia (AML) is one of the most common and fatal forms of hematopoietic malignancies. Here, we describe a mouse MLL-AF9_AML model to investigate …
Learning from mouse models of MLL fusion gene-driven acute …
5-10% of human acute leukemias carry chromosomal translocations involving the mixed lineage leukemia (MLL) gene that result in the expression of chimeric protein fusing MLL to >80 …
Dissecting the early steps of MLL induced leukaemogenic ... - Nature
2020年3月16日 · Here, we take advantage of cells conditionally blocked at the multipotent haematopoietic progenitor stage to develop a MLL-r model capturing early cellular and …
A human genome editing–based MLL::AF4 ALL model …
2023年11月16日 · Chromosomal translocations involving the mixed-lineage leukemia (MLL) gene drive leukemia development; key determinants of disease outcome are patient age, MLL …
Mouse models of MLL leukemia: recapitulating the human disease
This review provides an overview of different MLL-FP mouse model systems and discusses how well they have recapitulated aspects of the human disease as well as highlights the biological …