In probability theory, the Mills ratio (or Mills's ratio [1]) of a continuous random variable is the function ():= ¯ (), where () is the probability density function, and

MLL–ENL constructs in the absence of amino acids 430–475 at N-terminus of ENL continue to possess the ability to stimulate cell proliferation, whereas the deletion of C-terminus on ENL causes the fusion protein to lose its effect completely .

We found that MLL-ENL activates the splicing factor polypyrimidine tract binding protein-1 (PTBP1) to induce the anabolic state characteristic of transformed cells, and we showed that MLL-ENL–induced leukemia depends on an external supply of Ser/Gly, resulting in a potentially exploitable metabolic vulnerability.

2015年3月17日 · MLL fusion proteins constitutively activate the HOX genes, causing aberrant self-renewal. The modes of transcriptional activation vary depending on the fusion partners and can be categorized into at least four groups. Here I review the recent progress in research related to the molecular mechanisms of MLL fusion-dependent leukemogenesis.

2024年10月29日 · We propose MLL oncoproteins promote lineage-switching events through dynamic chromatin binding at lineage-specific target genes, and may support resistance to menin inhibitors through similar...

2017年1月9日 · We here explored this issue using an inducible mixed lineage leukemia-eleven nineteen leukemia (MLL-ENL) mouse model. Although multiple progenitor cell types with myeloid potential are potent AML...

2019年8月13日 · Our findings show that the efficiency of MLL-ENL-driven AML initiation changes through the course of pre- and postnatal development, and developmental programs can be manipulated to impede transformation.

2016年4月12日 · Here we report a strategy that identifies primary target genes of a conditionally transforming MLL-ENL protein that was created by insertion of a fusion of human ENL cDNA linked to a tamoxifen-inducible estrogen receptor into the mouse Mll locus (henceforth abbreviated MLL-ENL) (Takacova et al., 2012). By nascent RNA sequencing (RNA-seq), in ...

2016年7月8日 · Partial tandem duplication of MLL (MLL-PTD) characterizes acute myeloid leukemia (AML) patients often with a poor prognosis. To understand the order of occurrence of MLL -PTD in relation to other major AML mutations and to identify novel mutations that may be present in this unique AML molecular subtype, exome and targeted sequencing was ...

ENL/MLLT1 is a distinctive member of the KMT2 family based on its structural homology. ENL is a histone acetylation reader and a critical component of the super elongation complex.