2001年10月8日 · The SET domain of wild type MLL interacts with the tumor suppressor SNF5 (Rozenblatt-Rosen et al., 1998; Versteege et al., 1998) raising the possibility that loss of this interaction in MLL...

2004年2月1日 · SNF5 (also known as INI1), a core subunit of SWI/SNF, is specifically inactivated in malignant rhabdoid tumours, a highly aggressive cancer of early childhood. Whereas homozygous inactivation of...

2020年4月17日 · SWI/SNF complexes were first implicated in oncogenesis following the discovery that SMARCB1 (also known as INI1, SNF5 and BAF47; Box 1) is inactivated by biallelic mutations in nearly all cases...

In human acute myeloid and lymphoid leukaemia driven by MLL rearrangements (MLLr), transcriptional elongation is taking the centre stage in explaining the molecular mechanism of sustained transformation via increased transcriptional rate at select loci coding for proteins that are involved in the initiation or maintenance of the transformed state.

2022年1月6日 · In this study, we investigated the roles of SNF5 in melanoma and found that SNF5 responded to different levels of stiffness of matrix topography and affected melanoma cell proliferation and EMT. More importantly, SNF5 affected the immune escape of melanoma by activating the phosphorylating STAT3.

2008年8月18日 · Inactivation of SNF5 leads to aggressive tumors in children, and the median cancer onset following Snf5 loss in mouse models is remarkably short for inactivation of a single tumor suppressor. We hypothesized that the tumor suppressor activity of SNF5 arose not from a role in DNA repair or maintenance of genome integrity but rather from its role ...

2014年6月2日 · Pharmacological inhibition of the methyltransferase activity of EZH2 selectively inhibits growth of MRT cell lines with SNF5 mutations but not those with wild type SNF5 . These findings suggest a synthetic–lethal interaction between SNF5 and EZH2 and, consequently, offer a promising therapeutic approach in this disease.

2002年1月1日 · The chimeric fusion proteins MLL/AF10 and CALM/AF10, resulting from the t(10;11)(p12;q23) and the t(10;11)(p12;q14), respectively, consistently retain the leucine zipper motif of AF10. This part of the C-terminal region was used as bait in a yeast 2 hybrid screening of a testis complementary DNA library.

2010年9月24日 · MLL interacts with several proteins, including PcGs (such as BMI1 and PHC2), TrxGs (such as SNF5 and WDR5) and their accessory proteins (such as RBBP5, HDACs, and the HAT p300/CBP).

近年来，随着人类癌症外显子和全基因组测序等技术的迅速发展，众多研究发现 SWI/SNF （SWItch/Sucrose Non-Fermentable） 复合物 的亚基基因在多种肿瘤中呈现突变或失活，超过20%的肿瘤与该复合物突变有关 [1]。 哺乳动物SWI/SNF染色体重构复合物利用水解ATP释放能量来驱动核小体运动并调控染色体的结构。 SWI/SNF复合物 包含约15个亚基，不同的复合物组装调控干细胞在发育过程中的细胞命运。 但关于该复合物的组装和解聚是如何调控的作用机制尚 …