MLL1 regulates cytokine-driven cell migration and metastasis
2024年3月13日 · Overall, our studies show that MLL1 is an epigenetic regulator of 3D cancer cell migration, which exerts its effects by controlling the production of the key cytokines IL-6, IL-8, …
The histone lysine methyltransferase MLL1 regulates the ... - Cell …
2024年5月28日 · Here, we show that T cell-specific deletion of the lysine methyltransferase MLL1 results in a spontaneous lymphocyte proliferation phenotype in aged mice without disturbing …
Non-canonical MLL1 activity regulates centromeric phase ... - Nature
2023年11月9日 · Our results show a potential therapeutic strategy of targeting MLL1 in a subset of hepatocellular carcinoma (HCC) that exhibits a high level of chromosomal instability. We …
Inhibiting an RBM39/MLL1 epigenomic regulatory complex ... - Cell …
RBM39 is a known splicing factor and coactivator. Here, we report that RBM39 functions as a master transcriptional regulator that interacts with the MLL1 complex to facilitate chromatin …
MLL1 is required for PAX7 expression and satellite cell self
2019年9月18日 · In this study, we uncover a specific role of MLL1 in regulating PAX7 expression, elucidating their involvement in Myf5 transcriptional control. Using conditional alleles of Mll1 …
MLL1 and MLL1 fusion proteins have distinct functions in …
2016年5月17日 · Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in...
Structure, function and inhibition of critical protein–protein ...
2021年4月6日 · Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master regulator …
The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and ... - Cell …
2019年1月8日 · We show in a mouse tumor model of K14-Cre-induced Wnt / β-catenin gain-of-function and Bmpr1a loss-of-function mutations that tumor-propagating cells exhibit increased …
MLL1 and MLL1 fusion proteins have distinct functions in
2016年5月17日 · Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in …
MLL1 Promotes IL-7 Responsiveness and Survival during B Cell
2018年3月1日 · Genome-wide expression data illustrate that MLL1 is connected to B cell differentiation and IL-7-dependent survival through a complex transcriptional network. Overall, …