2024年3月13日 · Overall, our studies show that MLL1 is an epigenetic regulator of 3D cancer cell migration, which exerts its effects by controlling the production of the key cytokines IL-6, IL-8, and TGF-β1. Our in vivo studies demonstrate a potential combination anticancer therapy that can reduce metastatic burden via two separate molecular mechanisms.

2024年5月28日 · Here, we show that T cell-specific deletion of the lysine methyltransferase MLL1 results in a spontaneous lymphocyte proliferation phenotype in aged mice without disturbing the development of conventional T cells and Tregs. Treg-specific MLL1 ablation leads to a systemic autoimmune disease associated with Treg dysfunction.

2023年11月9日 · Our results show a potential therapeutic strategy of targeting MLL1 in a subset of hepatocellular carcinoma (HCC) that exhibits a high level of chromosomal instability. We performed two...

RBM39 is a known splicing factor and coactivator. Here, we report that RBM39 functions as a master transcriptional regulator that interacts with the MLL1 complex to facilitate chromatin binding and H3K4 trimethylation in breast cancer cells.

2019年9月18日 · In this study, we uncover a specific role of MLL1 in regulating PAX7 expression, elucidating their involvement in Myf5 transcriptional control. Using conditional alleles of Mll1 and Mll2, we...

2016年5月17日 · Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in...

2021年4月6日 · Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master regulator for transcription of important genes (e.g., Hox genes) for embryonic development and hematopoiesis. However, it is largely dispensable in matured cells.

2019年1月8日 · We show in a mouse tumor model of K14-Cre-induced Wnt / β-catenin gain-of-function and Bmpr1a loss-of-function mutations that tumor-propagating cells exhibit increased Mll1 activity and genome-wide increased H3K4 tri-methylation at promoters.

2016年5月17日 · Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in regulating global gene expression in MLLr cells, as well as its interplay with MLL1 fusion proteins remains unclear. Here we show that desp …

2018年3月1日 · Genome-wide expression data illustrate that MLL1 is connected to B cell differentiation and IL-7-dependent survival through a complex transcriptional network. Overall, our data demonstrate that wild-type MLL1 is a regulator of pre-BCR signaling and B cell differentiation and further suggest that targeting its function in pro-B cell ALL may be ...