2016年5月17日 · Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in...

2024年3月13日 · MLL1, with its scaffold protein Menin, controls actin filament assembly via the IL-6/8/pSTAT3/Arp3 axis and myosin contractility via the TGF-β1/Gli2/ROCK1/2/pMLC2 axis, which together regulate dynamic protrusion generation and 3D cell migration. MLL1 also regulates cell proliferation via mitosis-based and cell cycle–related pathways.

RBM39 is a known splicing factor and coactivator. Here, we report that RBM39 functions as a master transcriptional regulator that interacts with the MLL1 complex to facilitate chromatin binding and H3K4 trimethylation in breast cancer cells.

2012年9月1日 · MLL1 regulates the increased H3K4 trimethylation on the Nfkbia (IκBα) promoter induced by TNFα. (A) p65 was knocked down in the F-Mll1 MEF cell line by siRNA. A ChIP assay was performed to study the amount of F-Mll1 on chromatin. MLL1 bound to the promoters of Nfkbia and Sod2 in the untreated cell.

Menin 是一种接头蛋白和抑癌基因，由多发性内分泌肿瘤 1 (MEN1) 基因编码。Menin 还与 MLL1 的羧基末端相互作用，并作为 MLL1 和 MLL 融合蛋白的关键辅助因子发挥作用。

Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in...

2024年5月28日 · Here, we show that T cell-specific deletion of the lysine methyltransferase MLL1 results in a spontaneous lymphocyte proliferation phenotype in aged mice without disturbing the development of conventional T cells and Tregs. Treg-specific MLL1 ablation leads to a systemic autoimmune disease associated with Treg dysfunction.

Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role...

2024年12月22日 · MLL1 was highly expressed in placental tissues of PE mice. Inhibition of MLL1 improved PE symptoms in mice, repressed ferroptosis in placental tissues, and inhibited Erastin-induced ferroptosis in vitro. MLL1 elevated RBM15 expression by increasing H3K4me3 on …

2020年12月21日 · Here we identify the histone methyltransferase Mll1 as a regulator of Wnt-driven intestinal cancer. Mll1 is highly expressed in Lgr5 + stem cells and human colon carcinomas with increased...