MLL1 and MLL1 fusion proteins have distinct functions in …
2016年5月17日 · Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in...
MLL1 regulates cytokine-driven cell migration and metastasis
2024年3月13日 · MLL1, with its scaffold protein Menin, controls actin filament assembly via the IL-6/8/pSTAT3/Arp3 axis and myosin contractility via the TGF-β1/Gli2/ROCK1/2/pMLC2 axis, …
Inhibiting an RBM39/MLL1 epigenomic regulatory complex
RBM39 is a known splicing factor and coactivator. Here, we report that RBM39 functions as a master transcriptional regulator that interacts with the MLL1 complex to facilitate chromatin …
MLL1, a H3K4 methyltransferase, regulates the TNFα-stimulated ...
2012年9月1日 · MLL1 regulates the increased H3K4 trimethylation on the Nfkbia (IκBα) promoter induced by TNFα. (A) p65 was knocked down in the F-Mll1 MEF cell line by siRNA. A ChIP …
表观遗传学 | 混合谱系白血病 (MLL) | Cell Signaling Technology
Menin 是一种接头蛋白和抑癌基因，由多发性内分泌肿瘤 1 (MEN1) 基因编码。Menin 还与 MLL1 的羧基末端相互作用，并作为 MLL1 和 MLL 融合蛋白的关键辅助因子发挥作用。
Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in...
The histone lysine methyltransferase MLL1 regulates the …
2024年5月28日 · Here, we show that T cell-specific deletion of the lysine methyltransferase MLL1 results in a spontaneous lymphocyte proliferation phenotype in aged mice without disturbing …
ChIP-seq analyses for the MLL1 complex in the MLL-AF9 cells. (a ...
Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role...
MLL1 promotes placental trophoblast ferroptosis and aggravates ...
2024年12月22日 · MLL1 was highly expressed in placental tissues of PE mice. Inhibition of MLL1 improved PE symptoms in mice, repressed ferroptosis in placental tissues, and inhibited …
The epigenetic regulator Mll1 is required for Wnt-driven ... - Nature
2020年12月21日 · Here we identify the histone methyltransferase Mll1 as a regulator of Wnt-driven intestinal cancer. Mll1 is highly expressed in Lgr5 + stem cells and human colon …