Histone-lysine N-methyltransferase 2A, also known as acute lymphoblastic leukemia 1 (ALL-1), myeloid/lymphoid or mixed-lineage leukemia 1 (MLL1), or zinc finger protein HRX (HRX), is an enzyme that in humans is encoded by the KMT2A gene.

2024年12月25日 · KMT2A (Lysine Methyltransferase 2A) is a Protein Coding gene. Diseases associated with KMT2A include Wiedemann-Steiner Syndrome and Acute Myeloid Leukemia With T(9;11)(P22;Q23). Among its related pathways are Gene expression (Transcription) and Epigenetic regulation by WDR5-containing histone modifying complexes.

The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of acute leukemias. More than 80 different partner genes in these fusions have been ...

2016年5月17日 · Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role...

Chromosomal translocations that disrupt the Mixed Lineage Leukemia protein-1 gene (MLL1, ALL1, HRX, Htrx)) are associated with a unique subset of acute lymphoblastic or myelogenous leukemias [1–4]. The product of MLL1 gene is a large protein that functions as a transcriptional co-activator required for the maintenance of Hox gene expression ...

2021年4月6日 · Chromosome translocations involving mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) gene located at chromosome 11q23 cause approximately 75% of acute leukemia in infants and 5–10% in children and adults [1], which can be clinically characterized to be acute lymphocytic leukemia (ALL) or acute myeloid leukemia (AML).

We have demonstrated that the Mll1 gene is critical to Th1 differentiation in humans and mice; A subset of acute myeloid leukemias with MLL fusions are sensitive to MEK and receptor tyrosine kinase inhibitors. Results elucidate novel roles for polycomb and MLL/COMPASS in regulating DNA methylation and define targets of this regulation.

2024年10月15日 · The Mixed lineage leukemia 1 (MLL1) gene, located on chromosome 11q23, plays a pivotal role in histone lysine-specific methylation and is consistently associated with various types of leukemia. Non-synonymous Single Nucleotide Polymorphisms (nsSNPs) have been tied to numerous diseases, including cancers, …

2023年11月9日 · Inhibiting MLL1 activity or mutating Borealin K143 to arginine perturbs CPC phase separation, reduces Aurora kinase B activity, and impairs the resolution of erroneous kinetochore–microtubule...

2017年6月12日 · Co-deletion of Mll1 and Mll2 reveals collaborative rather than redundant activities. Mll2 and Mll1 together promote three major AML survival pathways. The MLL1 histone methyltransferase gene undergoes many distinct chromosomal rearrangements to yield poor-prognosis leukemia. The remaining wild-type allele is most commonly, but not always, retained.