Histone-lysine N-methyltransferase 2A, also known as acute lymphoblastic leukemia 1 (ALL-1), myeloid/lymphoid or mixed-lineage leukemia 1 (MLL1), or zinc finger protein HRX (HRX), is an …

2024年12月25日 · KMT2A (Lysine Methyltransferase 2A) is a Protein Coding gene. Diseases associated with KMT2A include Wiedemann-Steiner Syndrome and Acute Myeloid Leukemia …

The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of acute leukemias. More …

2016年5月17日 · Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role...

Chromosomal translocations that disrupt the Mixed Lineage Leukemia protein-1 gene (MLL1, ALL1, HRX, Htrx)) are associated with a unique subset of acute lymphoblastic or myelogenous …

2021年4月6日 · Chromosome translocations involving mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) gene located at chromosome 11q23 cause approximately 75% of …

We have demonstrated that the Mll1 gene is critical to Th1 differentiation in humans and mice; A subset of acute myeloid leukemias with MLL fusions are sensitive to MEK and receptor …

2024年10月15日 · The Mixed lineage leukemia 1 (MLL1) gene, located on chromosome 11q23, plays a pivotal role in histone lysine-specific methylation and is consistently associated with …

2023年11月9日 · Inhibiting MLL1 activity or mutating Borealin K143 to arginine perturbs CPC phase separation, reduces Aurora kinase B activity, and impairs the resolution of erroneous …

2017年6月12日 · Co-deletion of Mll1 and Mll2 reveals collaborative rather than redundant activities. Mll2 and Mll1 together promote three major AML survival pathways. The MLL1 …