The Mixed Lineage Leukemia 2 (MLL2) protein, also known as KMT2B, belongs to the family of mammalian histone H3 lysine 4 (H3K4) methyltransferases. It is a large protein of 2715 amino acids, widely expressed in adult human tissues and a paralog of ...

2021年8月12日 · MLL2 复合体负责特定基因启动子和附近的顺式调节位点上的 H3K4 三甲基化 (H3K4me3)，调节二价发育基因以及干细胞和生殖细胞分化基因集。 此外，MLL2 在发育中发挥着关键作用， Mll2的种系缺失与早期生长迟缓、神经管缺陷和导致胚胎死亡的细胞凋亡有关。

Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and sometimes MLL2 in humans and Mll4 in mice, is a major mammalian histone H3 lysine 4 (H3K4) mono-methyltransferase. [5] It is part of a family of six Set1-like H3K4 methyltransferases that also contains KMT2A (or MLL1), KMT2B (or MLL2), KMT2C (or MLL3), KMT2F (or SET1A), and ...

Histone-lysine N -methyltransferase 2D (KMT2D), also known as MLL4 and MLL2 in humans and Mll4 in mice, belongs to a family of mammalian histone H3 lysine 4 (H3K4) methyltransferases. It is a large protein over 5,500 amino acids in size and is …

As Mll2 functions as a methyltransferase for H3K4 and associates with non-TSS Mll2-associated sites enriched for H3K4me3, we reasoned that Mll2 may be the enzyme directly responsible for implementation of H3K4me3 at the non-TSS Mll2-associated sites.

2006年4月15日 · To look for evidence of gene-specific epigenetic regulation in mammalian development, we examined one of these six, Mll2, using a multipurpose allele in the mouse to ascertain the loss-of-function phenotype. Loss of Mll2 slowed growth, increased apoptosis and retarded development, leading to embryonic failure before E11.5.

2017年9月5日 · KMT2D is a major mammalian H3K4 mono-methyltransferase and co-localizes with lineage determining transcription factors on transcriptional enhancers. It is required for the binding of histone H3K27 acetyltransferases CBP and p300 on enhancers, enhancer activation and cell-type specific gene expression during differentiation.

2017年6月12日 · We show that Mll2 deletion reduced MLL-AF9 leukemia cell survival, and that the co-deletion of both Mll1 and Mll2 resulted in more severe reductions in survival, proliferation, and gene expression than either individual gene deletion.

mll 基因在人类癌症中经常发生突变。与 mll1 不同，mll2（也称为 alr/mll4）及其同系物 mll3 尚不清楚。具体而言，关于全局 mll2 参与基因表达调控的程度及其改变驱动肿瘤发生的机制知之甚少。在这里，我们分析了 mll2 靶向的全局基因座。

MLL2 is a tumor suppressor gene encoding histone H3 lysine 4 (H3K4) mono-methyltransferase, that colocalizes with lineage determining transcription factors on transcriptional enhancers and is essential for cell differentiation and embryonic development.