2024年12月25日 · MLX (MAX Dimerization Protein MLX) is a Protein Coding gene. Diseases associated with MLX include Ovarian Dysgenesis 3 and Takayasu Arteritis. Among its related pathways are Integration of energy metabolism and Metabolism.

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors.These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the …

MLX-Q139R mutation plays a crucial role in the pathogenesis of Takayasu arteritis through promoting inflammasome formation. MYC is part of a network of bHLHLZ proteins centered on the MYC heterodimeric partner MAX and its counterpart, the MAX-like protein MLX.

2023年9月9日 · Here, we show that MLX expression is elevated in HCC specimens and downregulation of MLX expression inhibits proliferation of HCC cells. In mice, liver-specific knockout of Mlx results in...

MLX is a prognostic marker in Kidney renal clear cell carcinoma, Liver hepatocellular carcinoma, Pancreatic adenocarcinoma

MAX 二聚化蛋白 MLX： 该基因的产物属于碱性螺旋-环-螺旋亮氨酸拉链 (bHLH-Zip) 转录因子家族。 这些因子与 Mad 蛋白形成异二聚体，并在增殖、决定和分化中发挥作用。

2020年3月19日 · Here we utilized genome-wide screening to identify genes that modulate lipid storage in macrophages, a cell type involved in metabolic diseases. Among ∼550 identified screen hits is MLX, a basic helix-loop-helix leucine-zipper transcription factor that regulates metabolic processes.

Mlx is an obligatory partner of ChREBP in regulating lipogenic enzyme genes in liver. The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation.

2024年3月5日 · MLX plays a key role in lipid and glucose metabolism in humans: Evidence from in vitro and in vivo studies. Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis. Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. Ma L, Tsatsos NG, Towle HCMa L, et al. J Biol Chem, 2005 Mar 25. PMID 15664996.

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation.

2023年7月1日 · Max-like protein factor X (MLX) acts as a heterodimer binding partner for glucose sensing transcription factors and inhibition of MLX or downstream targets has been shown to alleviate intrahepatic triglyceride (IHTG) accumulation in mice. However, its effect on insulin sensitivity remains unclear.

2000年7月5日 · In this paper, we describe the isolation of Mlx, a bHLHZip protein, in a screen for new Rox interactors. The same gene was independently identified in a screen for Mad1 interacting proteins...

The transcription factor MLX regulates glucose-induced myogenesis. (A) Increased Mlx expression is detected by quantitative PCR (qPCR) in muscle cells stably expressing MLX-WT and MLX-DN compared with control cells expressing an empty vector (EV) control. MLX shRNA decreases Mlx levels compared

MLX, also known as Max-like protein X, is a human protein encoded by the MLX gene. It belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors, which are involved in the regulation of various cellular processes including …

MLX的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为该基因的产物属于家庭的碱性螺旋 - 环 - 螺旋亮氨酸拉链（的bHLH-Zip的）转录因子。

The Mlx Network target gene repertoire, originally thought to regulate glucose and lipid metabolism, has recently been expanded to include additional roles in maintaining mitochondrial and ribosomal structure and function, aging, senescence, autophagy, apoptosis, and other functions (Figure 6A–E).

2020年3月19日 · Among ∼550 identified screen hits is MLX, a basic helix-loop-helix leucine-zipper transcription factor that regulates metabolic processes. We show that MLX and glucose-sensing family members MLXIP/MondoA and MLXIPL/ChREBP bind LDs via C-terminal amphipathic helices.

MLX has 4,682 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or …

2023年1月20日 · Max-like protein factor X (MLX) acts as a heterodimer binding partner for glucose sensing transcription factors and inhibition of MLX or downstream targets has been shown to alleviate intrahepatic triglyceride (IHTG) accumulation in mice. However, its effect on insulin sensitivity remains unclear.

1999年12月17日 · The effects of Mlx heterocomplexes on transcription were tested using a luciferase reporter gene under control of the SV40 promoter, which was made responsive to Max network proteins by cloning four copies of the CACGTG binding site upstream of the SV40 promoter sequences.