2019年4月10日 · The mitofusin 2 (MFN2) gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion to maintain and operate the mitochondrial network. Moreover, MFN2 is essential for mitophagy. In Ang II-induced cardiac remodeling, the combined effects of MFN2-mediated mitochondrial fusion and mitophagy are unclear.

2023年7月26日 · We hypothesized that MMP-2 proteolyzes Mfn-2 during myocardial IR injury, impairing mitochondrial function and enhancing the inflammasome response. Isolated hearts from mice subjected to IR injury (30 min ischemia/40 min reperfusion) showed a significant reduction in left ventricular developed pressure (LVDP) compared to aerobically perfused ...

The Ang II-induced increases in ROS production and apoptosis rate were alleviated by MFN2 overexpression. Moreover, MFN2 alleviated the Ang II-induced reduction in MMP. MFN2 promoted mitochondrial fusion, and MFN2 promoted Parkin translocation and phosphorylation, leading to mitochondrial autophagy.

2023年9月1日 · It has been reported that mTOR-mediated phosphorylation of MFN2 at Ser200 induces the interaction of PKM2 with MFN2 and increases OXPHOS capacity by increasing mitochondrial fusion, and decreases glycolysis capacity in tumor cells [49].

2024年2月12日 · Results showed that Irisin can suppress doxorubicin-induced upregulation of MMP2 and MMP9, thereby reducing the degradation of tight junction proteins (ZO-1 and Claudin-5) and VE-cadherin. The preservation of Claudin-5 contributes to maintaining Mfn2 expression, which in turn supports mitochondrial fusion.

2021年7月23日 · Mfn2 is a mitochondrial fusion protein with bioenergetic functions implicated in the pathophysiology of neuronal and metabolic disorders. Understanding the bioenergetic mechanism of Mfn2 may aid in designing therapeutic approaches for these disorders.

2021年9月15日 · A significantly decreased MMP was observed in MFN2 RNAi human spinal motor neurons compared with Luc RNAi group . These data indicate MFN2 is important for maintaining normal mitochondrial morphology and function, and MFN2 loss induced mitochondrial fragments and led to reduced mitochondrial health.

We recently observed that the ratio of mitofusin 2 (Mfn2; a fusion protein) and Drp-1 (a fission protein) was decreased during heart failure, suggesting increased mitophagy. Treatment with Mdivi-1 improved cardiac function by normalizing this ratio.

2025年2月10日 · Here we identify a role of MFN2 in quality control independent of its function in organellar shape remodeling. MFN2 ablation alters the cellular proteome, marked for example by decreased levels...

mfn2影响线粒体-er栓系，在ca2+信号转导中发挥关键作用，并在心肌组织和骨骼肌中高表达。 MFN2的突变能够导致20%的腓骨肌萎缩症，而MFN1的突变并没有引起疾病，这一事实也清楚地表明了功能上的差异。