mmp由促炎细胞和子宫胎盘细胞分泌，包括成纤维细胞、 成骨细胞 、 内皮细胞 、血管平滑肌、巨噬细胞、中性粒细胞、淋巴细胞和细胞滋养细胞等。真皮成纤维细胞和白细胞是mmp的主要来源，尤其是mmp-2。血小板是mmp-1、mmp-2、mmp-3和mmp-14的重要来源。

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such …

mmps可以降解基底膜和细胞外基质，与肿瘤的生长、发展密切相关，涉及肿瘤浸润、转移、血管生成。现已在多种人类肿瘤中检测到mmps的存在，如早期肝癌和甲状腺癌中存在mmp-i的表达，在人类结肠癌中mmp-2、mmp-7和mmp-9均过量表达，在乳腺癌中，已检测到mmp-8、mmp ...

2021年11月13日 · Matrix metalloproteinase 11 (MMP11), a member of the MMP family involved in the degradation of the extracellular matrix, has been implicated in cancer...

2024年12月25日 · MMP11 (Matrix Metallopeptidase 11) is a Protein Coding gene. Diseases associated with MMP11 include Cutaneous Fibrous Histiocytoma and Dermatofibrosarcoma Protuberans. Among its related pathways are Matrix metalloproteinases and Integrin Pathway.

MMP-11, also named stromelysin-3, is a member of the stromelysin subgroup belonging to MMPs superfamily, which has been detected in cancer cells, stromal cells and adjacent microenvironment. Differently, MMP-11 exerts a dual effect on tumors.

2025年1月15日 · MMP-11 (stromelysin-3) is produced during embryogenesis, tissue involution, wound healing, and has been linked to cancer (Chen et al., 2020). Recent studies suggest MMP-11, produced by cancer cells in adipose tissue, degrades collagen VI and contributes to tumor growth, indicating a link between obesity and cancer (Motrescu et al., 2008a).

Matrix metalloproteinase 11 (MMP11) in macrophages promotes the migration of HER2-positive breast cancer cells and monocyte recruitment through CCL2-CCR2 signaling. MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 protein.

Matrix metalloproteinase (MMP)-11, or Stromelysin 3, is a particular member of MMP family, a group of zinc-dependent endopeptidases involved in matrix degradation and tissue remodeling. Despite intense efforts since its first characterization 15 years ago, its role and target substrates in …

2012年11月2日 · Matrix metalloprotease 11 (MMP-11), a protease associated with invasion and aggressiveness of cancerous tissue, was postulated as a prognostic marker for pancreatic, breast, and colon cancer patients. Expression analysis, however, did not reveal localization and regulation of this protease.