Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such …

MMP由促炎细胞和子宫胎盘细胞分泌，包括成纤维细胞、 成骨细胞 、 内皮细胞 、血管平滑肌、巨噬细胞、中性粒细胞、淋巴细胞和细胞滋养细胞等。 真皮成纤维细胞和白细胞是MMP的主要来源，尤其是MMP-2。 血小板是MMP-1、MMP-2、MMP-3和MMP-14的重要来源。 它们存在于大多数结缔组织中。 MMP-1、MMP-2、MMP-3、MMP-7、MMP-8、MMP-9、MMP-12、MMP-13以及MT1-MMP和MT3-MMP在各种血管组织和细胞中表达。 MMPs通常以非活性的proMMP形式分 …

2024年12月25日 · MMP16 (Matrix Metallopeptidase 16) is a Protein Coding gene. Diseases associated with MMP16 include Seminoma and Glottis Squamous Cell Carcinoma. Among its related pathways are Matrix metalloproteinases and Extracellular matrix organization.

基质金属肽酶 16： 基质金属蛋白酶 (mmp) 家族的蛋白质参与正常生理过程 (如胚胎发育、繁殖和组织重塑) 以及疾病过程 (如关节炎和转移) 中细胞外基质的分解。

MMP16 is a putative indicator of adverse melanoma prognosis. Expression of MMP-16 in HTB9 and T24 cells increases following transforming growth factorbeta1 treatment. Matrix metalloproteinase 16 (MMP16) was a downstream target of miR-146b-5p.

Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

16 MMPs are a family of metal-dependent enzymes responsible for the degradation and remodeling of the extracellular matrix and basement membrane that occurs during both normal physiologic activity and disease. You might find these chapters and articles relevant to this topic.

Title: LncRNA NEAT1 regulates MMP-16 by targeting miR-200a/b to aggravate inflammation in asthma. Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC).

2024年3月4日 · Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen.

2024年12月16日 · 多因素Logistic分析结果显示，CCL18、MMP-16是CRC患者术后发生肿瘤复发转移的影响因素（P＜0.05）。 结论CRC根治术后患者血清CCL18、MMP-16水平较高，与肿瘤复发、转移密切相关。