2024年11月19日 · Recent findings indicate that macrophages can directly transdifferentiate into myofibroblasts (macrophage-to-myofibroblast transition, MMT), defined by the expression of both macrophage markers (F4/80 or CD68) and myofibroblast markers (α …

It can also promote the differentiation of macrophages under certain environmental conditions. The current study is intended to explore the role of CCR8 in macrophage to myofibroblast transdifferentiation (MMT) in IPF.

2024年12月20日 · Our study revealed that MMT was significantly activated in IPF in PMCs. IPF predominantly occur in subpleural and the mechanism is still poorly understood. Fibroblasts are generally considered to be the key effector cells in pulmonary fibrosis .

Epithelial to mesenchymal transition (EMT) and its cell specific variants endothelial to mesenchymal transition (EndMT) and mesothelial to mesenchymal transition (MMT) are physio-pathologic cellular reprogramming processes induced by several infectious, inflammatory and biomechanical stimuli.

2024年9月24日 · Macrophage-myofibroblast transformation (MMT) transforms macrophages into myofibroblasts in a specific inflammation or injury microenvironment. MMT is an essential biological process in fibrosis-related diseases involving the lung, heart, kidney, liver, skeletal muscle, and other organs and tissues.

2022年4月4日 · The results indicated that macrophages were differentiated into myofibroblast-like cells following TGF-β treatment, which could contribute to the complex fibroblast heterogeneity in IPF and underlined the prominent role of MMT in the pathogenesis of IPF.

2024年12月10日 · Macrophage–myofibroblast transdifferentiation (MMT), a fibrotic process impacting diverse tissue types, has garnered recent scholarly interest. Within damaged tissues, the role of myofibroblasts is pivotal in the accumulation of excessive fibrous connective tissue, leading to persistent scarring or organ dysfunction.

The expression of Mincle, as well as the proportion of CD14 + Mincle + cells, was significantly upregulated in the peripheral blood of AE-IPF and stable IPF patients in comparison with healthy subjects. Moreover, an increased expression of Mincle was detected in the patient’s lung tissues.

越来越多的证据支持肺泡上皮细胞间质转化（epithelial-mesenchymal transformation，EMT）在IPF发病机制中的作用，本文对特发性肺纤维化中EMT相关的主要信号转导通路研究进展作一综述。 EMT定义 EMT是一种上皮细胞去分化为可分泌细胞外基质（extracellular matrix，ECM）的间充质细胞，使纤维化病情长期存在，导致肺组织硬度增加...

本研究旨在探讨 ccr8 在 ipf 巨噬细胞向肌成纤维细胞转分化 (mmt) 中的作用。 方法：我们使用CCR8特异性小干扰RNA（siRNA）、自噬抑制剂（3-甲基腺嘌呤，3-MA）和激动剂（雷帕霉素）进行实验，探讨转化生长因子中巨噬细胞转分化为肌成纤维细胞的潜在机制-β（TGF-β ...