2021年2月9日 · In this study, we show that depletion of either MNK1 or MNK2 suppresses cell viability, anchorage-independent growth, and tumorigenicity of STS cells. We also identify a compelling...

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene. [5][6] MKNK1 has been shown to interact with MAPK1 [7] and Eukaryotic translation initiation factor 4 gamma. [8] ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

MAPK interacting kinase 1 (MNK1) has been shown to regulate both cap-dependent and internal ribosomal entry sites (IRES)-mediated mRNA translation. In this review we have discuss the role of MAPK in virus replication, particularly the role of MNK1 in replication and translation of viral genome. 1. Introduction.

2022年1月27日 · Mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1/2) represent a central class of enzymes that are activated by extracellular signal-regulated kinase (ERK) or p38 mitogen-activated protein (MAP) kinases. MNK1 and MNK2 coordinate cellular signaling, control production of inflammatory …

背景：MNK1和MNK2是与MAP激酶相互作用的丝氨酸/苏氨酸激酶，被RAS和MAPK信号通路激活，并参与蛋白质翻译的调控。 两种激酶都会在保守的丝氨酸209上磷酸化翻译起始因子eIF4E。 过度活化的eIF4E可以作为癌基因，在体外和体内均有助于转化，并在多种类型的癌症中高度表达。 有趣的是，同时缺少Mnk1和Mnk2的基因敲除小鼠没有任何明显的表型。 最近，首批双重MNK1 / 2抑制剂已与多西他赛联合治疗NSCLC和其他实体瘤，进入临床试验。 结果，人们对新型选 …

The mitogen-activated protein kinase (MAPK) interacting protein kinases 1 and 2 (Mnk1 and Mnk2) play important roles in controlling signals involved in mRNA translation. In addition to the MAPKs (p38 or Erk), multiple studies suggest that the Mnk ...

2024年12月25日 · MKNK1 (MAPK Interacting Serine/Threonine Kinase 1) is a Protein Coding gene. Diseases associated with MKNK1 include Glioma Susceptibility 1 and Leukemia, Acute Myeloid. Among its related pathways are Negative regulation of …

Mnk1 and Mnk2 are protein kinases that are directly phosphorylated and activated by extracellular signal-regulated kinase (ERK) or p38 mitogen-activated protein (MAP) kinases and implicated in the regulation of protein synthesis through their phosphorylation of …

1997年4月15日 · A novel clone isolated in this screen, designated MNK1, encodes a protein-serine/threonine kinase, which is most similar to MAP kinase-activated protein kinase 2 (MAPKAP-K2), 3pK/MAPKAP-K3 and p90RSK. Bacterially expressed MNK1 was phosphorylated and activated in vitro by ERK1 and p38 MAP kinases but not by JNK/SAPK.

2025年3月4日 · We discovered a class of ether-containing compounds with a high MNK1/2 selectivity. These MNK inhibitors show good potency in reducing cell viability and colony formation and have desirable pharmacokinetic properties. X-ray cocrystallization was accomplished to confirm the binding mode of our inhibitors and aid in future optimization.