2023年5月1日 · Proton pump inhibitors represent a class of medications used to treat a wide variety of pathologies related to the stomach's acid production. This activity reviews the indications, action, contraindications for proton pump inhibitors as a valuable agent in managing acid-related disorders.

Proton pump inhibitors (PPIs) block the gastric H,K-ATPase, inhibiting gastric acid secretion. This effect enables healing of peptic ulcers, gastroesophageal reflux disease (GERD), Barrett’s esophagus, and Zollinger-Ellison syndrome, as well as the eradication of Helicobacter pylori as part of combination regimens.

Proton pump inhibitor (PPI) is a prodrug which is activated by acid. Activated PPI binds covalently to the gastric H +, K + -ATPase via disulfide bond. Cys813 is the primary site responsible for the inhibition of acid pump enzyme, where PPIs bind.

2024年10月1日 · Mechanism of Action (MoA) describes the process by which a bioactive compound produces a pharmacological effect through the direct target interactions and the indirect modulation of related biochemical pathways [1].

The retention times were found to be 2.10 min for omeprazole, 3.34 min for lansoprazole and 4.54 min for pantoprazole. The method was linear in the following PPI concentrations: 2–20 mg/mL (lansoprazole), 2–36 mg/mL (omeprazole) and 0.5–20 mg/mL (pantoprazole).

Proton pump inhibitors (PPIs) are potent, highly selective inhibitors of the H+,K+–adenosine triphosphatase (ATPase) enzyme, which catalyzes the final step in gastric acid secretion.

2019年4月13日 · Proton pump inhibitors (PPIs) are drugs widely used to potently suppress gastric acid secretion in the therapy of gastroesophageal diseases. These drugs are activated in the acidic environment of the stomach and bind covalently to sulfhydryl groups of cysteines found in the proton pump (an H +,K + -ATPase) inactivating it.

Affiliation 1 Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.

2020年10月26日 · Proton-pump inhibitors reduce stomach acid production through irreversible inhibition of the proton pump – the H + /K + -ATPase, a pump present in gastric parietal cells. In this way, proton-pump inhibitors differ from H2 receptor antagonists (for example – ranitidine).

2021年4月13日 · Proton pump inhibitors. These agents are used in patient with peptic ulcers (who have failed to respond H2 Blocker). Mechanism of Action. It acts by inhibiting proton pump which is final common step