Nitroglycerin: Uses, Interactions, Mechanism of Action
Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension. 11
Nitroglycerin - StatPearls - NCBI Bookshelf - National Center for ...
2023年7月31日 · Nitroglycerin is a vasodilatory drug used primarily to provide relief from anginal chest pain. It is currently FDA approved for the acute relief of an attack or acute prophylaxis of angina pectoris secondary to coronary artery disease.
Nitroglycerin - Wikipedia
Nitroglycerin (NG) (alternative spelling of nitroglycerine), also known as trinitroglycerol (TNG), nitro, glyceryl trinitrate (GTN), or 1,2,3-trinitroxypropane, is a dense, colorless or pale yellow, oily, explosive liquid most commonly produced by nitrating glycerol with white fuming nitric acid under conditions appropriate to the formation of ...
Nitroglycerin: Dosage, Mechanism/Onset of Action, Half-Life
2020年2月17日 · Mechanism of Action. Nitroglycerin forms free radical nitric oxide. In smooth muscle, nitric oxide activates guanylate cyclase which increases guanosine 3’5’ monophosphate (cGMP) leading to dephosphorylation of myosin light chains and smooth muscle relaxation.
Nitroglycerin (medication) - Wikipedia
Nitroglycerin, also known as glyceryl trinitrate (GTN), is a vasodilator used for heart failure, high blood pressure (hypertension), anal fissures, painful periods, and to treat and prevent chest pain caused by decreased blood flow to the heart or due to the recreational use of cocaine.
The Role of Nitroglycerin and Other Nitrogen Oxides in …
In this review, we detail the discovery of nitroglycerin and its early use in the treatment of angina; the history of the discovery of nitric oxide, its sources, and its roles; the mechanism of action, preparations, and hemodynamic and non-hemodynamic effects of the organic nitrates, as well as their biotransformation; and the clinical uses and ...
Nitroglycerin - PubMed
2023年7月31日 · Nitroglycerin is a vasodilatory drug used primarily to provide relief from anginal chest pain. It is currently FDA approved for the acute relief of an attack or acute prophylaxis of angina pectoris secondary to coronary artery disease. Off-label, non-FDA-approved uses include treatment for hypertens …
After 130 years, the molecular mechanism of action of nitroglycerin …
The article by Chen et al. uncovers the role of mitochondrial aldehyde dehydrogenase, which specifically generates 1,2-glyceryl dinitrate from nitroglycerin, in the bioactivation of nitroglycerin to elicit vasorelaxation and in the development of tolerance to nitroglycerin.
nitroglycerin [TUSOM | Pharmwiki] - Tulane University
2022年11月6日 · Sublingual nitroglycerin is the drug of choice for acute treatment of angina due to its rapid onset of action & clinical efficacy
Mechanism of Action of Nitroglycerin: Coronary, Cardiac, and …
Despite the frequent, daily administration to patients with coronary disease and many investigations of these drugs in patients and experimental animals, their mechanism of action is still incompletely understood. This is in part because nitrates affect systemic vessels and the heart as well as coronary vessels.