2023年5月1日 · Proton pump inhibitors represent a class of medications used to treat a wide variety of pathologies related to the stomach's acid production. This activity reviews the indications, action, contraindications for proton pump inhibitors as a valuable agent in managing acid-related disorders.

Proton pump inhibitors (PPIs) block the gastric H,K-ATPase, inhibiting gastric acid secretion. This effect enables healing of peptic ulcers, gastroesophageal reflux disease (GERD), Barrett’s esophagus, and Zollinger-Ellison syndrome, as well as the eradication of Helicobacter pylori as part of combination regimens.

2024年5月31日 · Proton pump inhibitors (PPIs) effectively block gastric acid secretion by irreversibly binding to and inhibiting the hydrogen-potassium ATPase pump that resides on the luminal surface of the parietal cell membrane. This topic review will provide an overview of the mechanism of action, pharmacokinetics, administration, and adverse effects of PPIs.

The proton pump inhibitor (PPI), introduced in 1989, targeted the gastric H +, K + -ATPase and reflected a major medical therapeutic breakthrough in the treatment of peptic ulcers and GERD, resulting in more rapid healing of the lesions and symptom relief. PPI is a prodrug which is activated by acid.

2017年9月12日 · Pantoprazole is a proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid.

Cathepsin B / antagonists & inhibitors Cysteine Endopeptidases / metabolism Cysteine Proteinase Inhibitors / adverse effects* Endothelium, Vascular / drug effects Endothelium, Vascular / pathology Humans Lansoprazole / pharmacology Omeprazole / adverse effects Oxidative Stress / drug effects Proton Pump Inhibitors / adverse effects*

Proton pump inhibitors (PPIs) are drugs widely used to potently suppress gastric acid secretion in the therapy of gastroesophageal diseases. These drugs are activated in the acidic environment of the stomach and bind covalently to sulfhydryl groups of cysteines found in the proton pump (an H (+) ,K (+) -ATPase) inactivating it.

2016年11月9日 · Proton pump inhibitors are widely used in upper gastrointestinal diseases, including gastric and duodenal ulcers, eradication of Helicobacter pylori in combination with antibiotics, gastroesophageal reflux disease, Zollinger–Ellison syndrome, eosinophilic esophagitis, and prevention of non-steroidal anti-inflammatory drug-induced peptic ...

Proton pump inhibitors represent a class of medications used to treat a wide variety of pathologies related to the stomach's acid production. This activity reviews the indications, action, contraindications for proton pump inhibitors as a valuable …

2018年8月22日 · Proton pump inhibitors are the last, most effective GI medication to bring down the production of acid in the stomach. One of the well-known brands of PPIs is Protonix with a generic name of Pantoprazole.