Structural basis for autoinhibition and its relief of MOB1 in
2016年6月23日 · MOB1 protein is a key regulator of large tumor suppressor 1/2 (LATS1/2) kinases in the Hippo pathway. MOB1 is present in an autoinhibited form and is activated by …
张宏权教授团队发现氧化应激调节Hippo信号通路激活抑制肺癌细 …
2022 年 3 月 30 日，北京大学基础医学院的张宏权教授团队在 Nucleic Acids Research 杂志上在线发表了题为 “Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo …
Regulation of Protein Interactions by Mps One Binder (MOB1 ...
2017年6月1日 · MOB1 is a multifunctional protein best characterized for its integrative role in regulating Hippo and NDR pathway signaling in metazoans and the Mitotic Exit Network in …
MOB 激酶激活因子 1A（MOB1A）基因 | MCE - MCE-生物活性 ...
该基因编码的蛋白质是 Hippo 信号通路的一个组成部分，它通过增强细胞凋亡来控制器官大小和肿瘤生长。 编码蛋白的丢失导致细胞增殖和癌症形成。 编码的蛋白质还参与胞质分裂过程中微 …
MOB1 Mediated Phospho-recognition in the Core Mammalian
2017年6月1日 · Studies of yeast Mob1 and human MOB1 revealed that the ability to recognize phosphopeptide sequences in their interactors, Nud1 and MST2 respectively, was critical to …
MOB1, an Essential Yeast Gene Required for Completion of …
Mob1p is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature. MOB1 exhibits …
自身抑制的结构基础及其在 Hippo 通路中 MOB1 的缓解 …
MOB1 蛋白是 Hippo 通路中大肿瘤抑制因子 1/2 (LATS1/2) 激酶的关键调节因子。 MOB1 以自抑制形式存在，并被 MST1/2 介导的磷酸化激活，尽管由于缺乏自抑制 MOB1 结构，负责自抑制 …
NMR Solution Structure of Mob1, a Mitotic Exit Network Protein and …
2004年3月12日 · Here we report the solution structure of the Mob1 protein from Xenopus laevis solved by heteronuclear multidimensional NMR. The structure reveals a fold constituted by a …
Regulation of Protein Interactions by M ps O ne B inder (MOB1 ...
MOB1 is a multifunctional protein best characterized for its integrative role in regulating Hippo and NDR pathway signaling in metazoans and the Mitotic Exit Network in yeast. Human MOB1 …
Saccharomyces cerevisiae Mob1p Is Required for Cytokinesis and …
We investigated whether S. cerevisiae MOB1 is required for cell cycle processes other than SPB duplication and mitotic exit, and here we present genetic and cytological evidence that MOB1 …