2020年4月17日 · Pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) is mediated by mitogen-activated protein kinases and the majority of PTI defense genes are regulated by MPK3, MPK4 and MPK6. These responses have been mainly analyzed at the transcriptional level, however many splicing factors are direct targets of MAPKs.

2010年12月14日 · In this study, MPK4 is shown to be involved in the regulation of mitosis/cytokinesis through modulation of the cell division plane and cytokinetic progression. Cytokinesis, the cytoplasmic partitioning of the daughter nuclei following mitosis, is a temporally and spatially controlled process (Smith, 2001; Müller et al., 2009).

2019年8月9日 · Mitogen activated protein kinase 4 (MPK4) is a multifunctional kinase that regulates various signaling events in plant defense, growth, light response and cytokinesis. The question of how a single protein modulates many distinct processes has spurred extensive research into the physiological outcomes resulting from genetic perturbation of MPK4.

2018年9月11日 · Here, we show that mpk12 plants, in which MPK4 is stably silenced specifically in guard cells (mpk12 mpk4GC homozygous double-mutants), completely lack CO 2 -induced stomatal responses and have impaired activation of guard cell S-type anion channels in response to elevated CO 2 /bicarbonate.

2024年10月30日 · 近日，浙江大学 徐娟课题组在 Plant Physiology发表了题为“ Chemical-sensitized MITOGEN-ACTIVATED PROTEIN KINASE 4 provides insights into its functions in plant growth and immunity”的研究论文。 该研究建立了一个条件型失活mpk4突变体研究体系，对MPK4在植物生长/发育和免疫过程中的功能提出了新见解。 通过定点突变改变激酶ATP-binding pocket的空间结构后，激酶的活性可被ATP结构类似物NA-PP1特异抑制，从而导致该激酶无 …

MPK4 is highly expressed in guard cells, specialized epidermal cells forming stomatal pores on leaf surface that function at the frontline of bacterial pathogen invasion. In addition to biotic stresses, stomatal guard cells also mediate cellular responses to abiotic stimuli such as drought and CO2 changes.

2022年1月14日 · Mitogen-activated protein kinase 4 (MPK4) was first identified as a negative regulator of systemic acquired resistance. It is also an important kinase involved in many other biological processes in plants, including cytokinesis, reproduction, and photosynthesis. Arabidopsis thaliana mpk4 mutant is dwarf and sterile.

Mitogen-activated protein kinase (MPK) cascades are highly conserved signaling pathways that respond to environmental cues. Arabidopsis MPK4 has been identified as a stress-responsive protein kinase. Here we demonstrate that Brassica napus MPK4 (BnMPK4) is activated by hydrogen peroxide (H2O2) and p …

2008年11月4日 · Mitogen-activated protein kinase (MAPK) cascades play important roles in regulating plant innate immune responses. In a genetic screen to search for mutants with constitutive defense responses, we...

MPK4是植物免疫的负调节因子 (Petersen et al ., 2000 )，通过其上游信号成分MKK1/MKK2/MKK6被磷酸化激活 (Gao et al ., 2008；Lian et al ., 2018 )，从而协调基础免疫耐药性和效应物触发免疫（ETI；Zhang et al ., 2012）。 MPK4 的作用被 MAPK MPK3 和 MPK6 的相反作用所抵消（Bigeard 等， 2015）。 MPK4 级联的完整性由 R 蛋白核苷酸结合富含亮氨酸重复序列 (NB-LRR) 蛋白 mkk1、 mkk2 (SUMM2) 和 SNM1 的抑制剂来保护 (Zhang 等人， …