Positive results for myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies (ANCA) by antigen-specific immunoassay and perinuclear ANCA by indirect immunofluorescence are consistent with the diagnosis of microscopic polyangiitis (MPA) or eosinophilic granulomatosis with polyangiitis, in patients with the appropriate clinical presentation.

Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. [5] MPO is most abundantly expressed in neutrophils (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity, including hypochlorous acid, the sodium salt of which is the chemical in bleach.

MPO catalyzes the conversion of hydrogen peroxide to hypochlorite and hypochlorous acid. MPO is encoded by a single gene that undergoes posttranslational modification to produce the active enzyme found in leukocytes.

MPO is a white blood cell-derived inflammatory enzyme that measures disease activity from the luminal aspect of the arterial wall. Briefly, when the artery wall is damaged, or inflamed, MPO is released by invading macrophages where it accumulates.

抗髓过氧化物酶抗体（MPO）属于抗中性粒细胞胞浆抗体（ANCA）的一种，针对中性粒细胞和单核粒细胞的细胞浆成分。 临床检测方法有酶联免疫吸附法（ELISA）、间接免疫荧光法，其中间接免疫荧光法是一种初筛方法。 ANCA是鉴别诊断自身免疫性血管炎的重要标记物，而抗MPO抗体则与血管炎相关，可见于多种疾病中。 进行抗髓过氧化物酶抗体检测的指征有：①不明原因发热、体重降低、不适乏力、关节痛和关节炎等全身症状持续甚或导致身体多系统损害。 ②活动性肾 …

Myeloperoxidase Antibody (MPO) - Autoimmune vasculitis diseases are characterized by abnormal immune responses that result in inflammation and necrosis of blood vessels. The immune dysfunction may be triggered by infection, autoimmune disease, or exposure to a drug; often the cause is unknown.

Myeloperoxidase (MPO) antigen is covalently coupled to polystyrene microspheres that are impregnated with fluorescent dyes to create a unique fluorescent signature. MPO antibodies, if present in diluted serum, bind to the MPO antigen on the microspheres. The microspheres are washed to remove extraneous serum proteins.

For patients with a history of vasculitis, refer to Myeloperoxidase (MPO) Antibody and Serine Proteinase 3 (PR3) Antibody with Reflex to Anti-Neutrophil Cytoplasmic Antibody, IgG by IFA . New York DOH Approval Status

MPO is a white blood cell-derived inflammatory enzyme that measures disease activity from the luminal aspect of the arterial wall. Briefly, when the artery wall is damaged, or inflamed, MPO is released by invading macrophages where it accumulates1.

Anti-myeloperoxidase (MPO) antibodies are important for testing in a medical process called the Neutrophil Cytoplasmic Antibodies (ANCA) panel. This test helps doctors identify and tell apart certain autoimmune diseases that affect the blood vessels, mainly microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA).