Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. [5] MPO is most abundantly expressed in neutrophils (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity, including hypochlorous acid, the sodium salt of which is the chemical in bleach.

髓过氧化物酶(Myeloperoxidase，MPO)，又称过氧化物酶，是血红素辅基的血红素蛋白酶，是血红素过氧化物酶超家族成员之一。 MPO来源于中性粒细胞，单核细胞和巨噬细胞。

Myeloperoxidase is a hallmark enzyme of acute myeloid lineage and the clinical relevance of the circulating MPO level in acute myeloid leukemia (AML) patients showed higher plasma MPO levels (range 1.0–9514 ng/mL) as compared to control subjects (range 3.5–20.6 ng/mL) .

Myeloperoxidase (MPO) is an enzyme with remarkable diversity in health and disease. • MPO levels usually correlate with disease severity and is a key biomarker. • MPO has roles in COVID-19, drug oxidation, & neutrophil extracellular traps. • Clinical MPO inhibitors require further study to elucidate protective activity. 1.

髓过氧化物酶（英語： Myeloperoxidase ，简称为MPO）是一种由人类17号染色体上MPO基因编码的过氧化物酶 [6] 。 MPO主要表达于 中性粒细胞 （ 白细胞 的一种）中，并产生次卤酸，发挥其 抗菌 活性 [ 6 ] [ 7 ] 。

Myeloperoxidase is a lysosomal enzyme, located in the azurophilic granules of the neutrophils and its precursors, eosinophils and monocytes. This MPO stain is mainly used to differentiate acute myeloid leukaemia from acute lymphoblastic leukaemia. MPO stain can be a …

2018年2月15日 · Myeloperoxidase (MPO) is a heme-containing peroxidase expressed mainly in neutrophils and to a lesser degree in monocytes. In the presence of hydrogen peroxide and halides, MPO catalyzes the formation of reactive oxygen intermediates, including hypochlorous acid (HOCl). The MPO/HOCl system plays an …

Myeloperoxidase (MPO) is a tetrameric, heavily glycosylated inflammatory enzyme whose first recognized clinical role was in the contribution to the innate immune system [84]. MPO is released from polymorphonuclear neutrophils and macrophages and functions to form different reactive oxygen species.

2024年12月25日 · Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a …

Myeloperoxidase (MPO) is a heme-containing enzyme that, in the presence of peroxide and halide ions, is effective in killing various microorganisms; in addition, it exerts a wide variety of extracellular functions. Polymorphonuclear leukocytes (PMN) are the main source of this enzyme.