Positive results for myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies (ANCA) by antigen-specific immunoassay and perinuclear ANCA by indirect immunofluorescence are consistent with the diagnosis of microscopic polyangiitis (MPA) or eosinophilic granulomatosis with polyangiitis, in patients with the appropriate clinical presentation.

抗髓过氧化物酶抗体（mpo）属于抗中性粒细胞胞浆抗体（anca）的一种，针对中性粒细胞和单核粒细胞的细胞浆成分。 临床检测方法有酶联免疫吸附法（ELISA）、间接免疫荧光法，其中间接免疫荧光法是一种初筛方法。

2025年3月11日 · Co-localization of MPO and IgG (but not IgM) has been shown in multiple studies 8 9 12. MPO has been identified within glomeruli by mass spectrometry, without other dominant protein antigens in patients with concurrent crescentic GN and MN, demonstrating that MPO is the target antigen in these patients 10. MPO in this study as well as our ...

Myeloperoxidase (MPO) antigen is covalently coupled to polystyrene microspheres that are impregnated with fluorescent dyes to create a unique fluorescent signature. MPO antibodies, if present in diluted serum, bind to the MPO antigen on the microspheres.

髓过氧化物酶 (myeloperoxidase， MPO)又称过氧化物酶，是血红素辅基的血红素蛋白酶，是血红素过氧化物酶超家族成员之一。 存在于髓系细胞 (主要是中性粒细胞和单核细胞)的嗜苯胺蓝颗粒中，是髓细胞的特异性标志，随着对MPO研究的深入，人们发现MPO基因多态性导致个体对一些疾病易感性的差异，与人类多种疾病的发生、发展密切相关，因此越来越受到国内外学者的重视。 MPO基因多态性. 人髓过氧化物酶基因位于染色体17q23?q24，含有12个外显子和11个内含 …

For patients with a history of vasculitis, refer to Myeloperoxidase (MPO) Antibody and Serine Proteinase 3 (PR3) Antibody with Reflex to Anti-Neutrophil Cytoplasmic Antibody, IgG by IFA (3003746). Indicates whether a test has been approved by the New York State Department of Health. This test is New York state approved.

大量临床研究结果表明，mpo水平变化与 心肌梗死 （ami）发病密切相关，急性冠脉综合征（acs）患者血清中mpo含量显著升高，故mpo可作为急性冠脉综合征（acs）患者发生心血管不良事件的一个新的预测因子，特别是在肌钙蛋白水平较低情况下，mpo能够识别那些 ...

mpo抗体（266-6k1）是一种igg1鼠单克隆mpo抗体（也称为髓过氧化物酶抗体），可通过wb、ip和if检测人源mpo蛋白。mpo抗体（266-6k1）以非偶联抗mpo抗体的形式提供。血红素蛋白髓过氧化物酶（mpo）是中性粒细胞和多形核白细胞嗜苯胺蓝颗粒的主要成分。

Test ID MPO Myeloperoxidase Antibodies, IgG, Serum Useful For Evaluating patients with clinical features anti-neutrophil cytoplasmic antibody associated vasculitis, specifically granulomatosis with polyangiitis, microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis

髓过氧化物酶（MPO）是中性粒细胞嗜天青颗粒中的一种主要成分，可对抗细菌，对杀灭微生物有重要作用。 抗髓过氧化物酶抗体则影响MPO的功能而参与致病，一般用于检测坏死性血管炎或特发性新月体肾小球肾炎，但也可见于其他疾病。 抗MPO抗体. 抗髓过氧化物酶抗体是以细胞质内髓过氧化物酶为靶抗原的自身抗体，属于抗中性粒细胞胞浆抗体（ANCA）的一种，主要识别MPO，参与血管炎相关疾病的发病机制。 抗MPO抗体滴度与疾病活动性相关，可用于早期诊 …

Myeloperoxidase (MPO) is a peroxidase enzyme that is part of the host defense system of polymorphonuclear leukocytes. Heightened MPO levels have been associated with tissue damage and a number of pathological conditions.

Myeloperoxidase (MPO) antibodies are used for evaluating patients suspected of having immune-mediated vasculitis, especially microscopic polyangiitis (MPA), when used in conjunction with clinical history, physical examination, and other autoantibody tests.

Myeloperoxidase (MPO) enzyme is found in neutrophil primary granules and monocyte lysosomes. MPO catalyzes the conversion of hydrogen peroxide to hypochlorite and hypochlorous acid. MPO is encoded by a single gene that undergoes posttranslational modification to produce the active enzyme found in leukocytes.

抗髓过氧化物酶抗体是抗中性粒细胞胞浆抗体的一种，抗髓过氧化物酶抗体阳性的意义是提示机体存在血管病变，在临床上主要用于原发性血管炎、结节性多动脉炎、系统性红斑狼疮、类风湿关节炎、干燥综合征、系统性硬化症等疾病的诊断或筛查。 需前往医院进行进一步检查，明确病因后进行相应处理。 1、原发性血管炎： 由于血管壁破坏、炎性细胞浸润而导致阳性，如原发性肾小球肾炎，可表现为发热、皮疹、关节酸痛、腰背痛等症状； 2、结节性多动脉炎： 由于病毒、细菌 …

Myeloperoxidase is an enzyme in certain white blood cells that helps fight infections. Anti-MPO antibodies are produced when your body wrongly targets this enzyme, leading to a type of vasculitis associated with ANCA. These antibodies are mainly of the IgG type and can be detected using specific lab tests.

Positive results for myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies (ANCA) by antigen-specific immunoassay and perinuclear ANCA by indirect immunofluorescence are consistent with the diagnosis of microscopic polyangiitis (MPA) or eosinophilic granulomatosis with polyangiitis, in patients with the appropriate clinical presentation.

·用 途： [预期用途]用于体外定性检测人血清或血浆中的抗髓过氧化物酶（mpo）、蛋白酶3（pr3）、肾小球基底膜（gbm）的igg类抗体。 适应症：韦格纳肉芽肿、显微多动脉炎、肺肾综合征。

Anti-MPO antibodies were detected using a direct-binding enzyme-linked immunosorbent assay (ELISA) with MPO from human granulocytes as antigen. The IgG subclass of anti-MPO antibodies was determined by ELISA using isotype specific monoclonal antibodies.

Myeloperoxidase (MPO) antibodies are used for evaluating patients suspected of having immune-mediated vasculitis, especially microscopic polyangiitis (MPA), when used in conjunction with clinical history, physical examination, and other autoantibody tests.