Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. [5] MPO is most abundantly expressed in neutrophils (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity, including hypochlorous acid, the sodium salt of which is the chemical in bleach.

MPO catalyzes the reaction of hydrogen peroxide and chloride (or other halides) to produce hypochlorous acid and other potent antimicrobial oxidants. Knockout mice of MPO are impaired in clearing select microbial infections (6).

大量临床研究结果表明，mpo水平变化与 心肌梗死 （ami）发病密切相关，急性冠脉综合征（acs）患者血清中mpo含量显著升高，故mpo可作为急性冠脉综合征（acs）患者发生心血管不良事件的一个新的预测因子，特别是在肌钙蛋白水平较低情况下，mpo能够识别那些 ...

Myeloperoxidase (MPO) is an enzyme with remarkable diversity in health and disease. MPO levels usually correlate with disease severity and is a key biomarker. MPO has roles in COVID-19, drug oxidation, & neutrophil extracellular traps. Clinical MPO inhibitors require further study to elucidate protective activity. 1.

81610-1-RR targets MPO in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for …

2024年3月6日 · MPO的本质是一种金属四聚体糖基化蛋白，分子量为140kDa，由两条重链和两条轻链组成，分别为55和13.5 kDa。 主要储存于中性粒细胞的嗜天青颗粒中。 MPO是中性粒细胞活化的标志物，其水平和活性代表着种细胞粒细胞的功能和状态。

MPO is a dimeric protein and each dimer contains a 60-kD heavy unit and a 12-kD light subunit. The primary translation product is a single 80-kD protein that undergoes cotranslational glycosylation, proteolytic processing, and lysosomal targeting during the promyelocytic stage of myeloid development (Nauseef et al., 1988).

MPO Antibody is an unconjugated, approximately 84 kDa, rabbit-derived, anti-MPO polyclonal antibody. MPO Antibody can be used for: ELISA, IHC-P, IHC-F, ICC, IF expriments in human, mouse, and predicted: rat, dog, horse, rabbit, guinea pig background without labeling.

The 150-kDa MPO protein is a dimer consisting of two 15-kDa light chains and two variable-weight glycosylated heavy chains bound to a prosthetic heme group. Three isoforms have been identified, differing only in the size of the heavy chains.