2018年12月1日 · To determine whether MR1 was associated with B2M, immunoprecipitation of MR1 was done with and without exogenously added MR1 ligands. The results showed that …

The results showed that MR1 does not associate with B2M when no ligand is present. Treatment with BFA and acetyl-6-FP demonstrated B2M in association with MR1 in the ER, but MR1 was …

然而，mr1类似于传统的mhc i类分子，需要β2微球蛋白（b2m）来呈递。 因此，MR1限制性T细胞可能对B2M位点杂合性缺失的肿瘤不起作用，而这是高ITH的肿瘤逃避免疫监视的常见机制。

High-quality MR1 & B2M proteins from ACROBiosystems. Various species and tags of MR1 & B2M proteins. Minimal Batch-to-Batch Variation. Bulks in stock.

2024年12月25日 · MR1 (Major Histocompatibility Complex, Class I-Related) is a Protein Coding gene. Diseases associated with MR1 include Immune Deficiency Disease and Paroxysmal …

2021年11月29日 · MHC class I–related protein, MR1, presents vitamin B metabolites to αβ T cells known as mucosal-associated invariant T cells, diverse MR1-restricted T cells, and a subset of …

2020年9月21日 · We show that the endoplasmic reticulum (ER) contains a pool of two unliganded MR1 conformers stabilized via interactions with chaperones tapasin and tapasin-related …

2020年2月5日 · Researchers identify a new population of cytotoxic T cells that recognize the non-polymorphic MHC class I-related molecule MR1 on multiple different cancer cells, raising the …

2024年12月24日 · B2M (Beta-2-Microglobulin) is a Protein Coding gene. Diseases associated with B2M include Immunodeficiency 43 and Amyloidosis, Hereditary Systemic 6. Among its …

Beta-2 微球蛋白 (B2M) 对于通过 MHC I 类分子向免疫系统呈递抗原至关重要。 它与 α 链形成异二聚体，以产生 MHC I 类分子。 B2M 还与 MR1 和代谢物抗原形成异源三聚体，增强抗原呈递 …