2021年5月30日 · By replacing the 3x3 convolution with the PSA module in the bottleneck blocks of the ResNet, a novel representational block named Efficient Pyramid Squeeze Attention (EPSA) is obtained. The EPSA block can be easily added as a plug-and-play component into a well-established backbone network, and significant improvements on model performance can ...

2014年8月4日 · We have developed a supercritical fluid chromatography technique for peptides, termed EPSA, which is shown here to enable improved permeability design. Through assessing the exposed polarity of a peptide, this technique can be used as a permeability surrogate.

2016年12月30日 · EPSA is an experimental descriptor of molecular polarity obtained from chromatographic retention in supercritical fluid chromatography (SFC) systems, previously shown by Goetz et al. to correlate with passive permeability of cyclic peptides. The present study focuses on EPSA in relation to passive permeability of small molecules.

We have developed a supercritical fluid chromatography technique for peptides, termed EPSA, which is shown here to enable improved permeability design. Through assessing the exposed polarity of a peptide, this technique can be used as a permeability surrogate. Keywords: EPSA, cyclic peptides, permeability, polarity, intramolecular hydrogen bonding

2024年8月22日 · In the effort of translating EPSA to human in vitro and in vivo passive permeability, we demonstrated the application of EPSA for predicting Caco-2 cell and human intestinal permeability, showing improvements over topological polar surface area and the parallel artificial membrane permeability assay for rank-ordering permeability in a ...

• A novel Efficient Pyramid Squeeze Attention (EPSA) block is proposed, which can ef-fectively extract multi-scale spatial information at a more granular level and develop a long-range channel dependency. The proposed EPSA block is very flexible and scalable and thus can be applied to a large variety of network architectures for numerous ...

2023年1月5日 · Experimental Polar Surface Area (EPSA) is an experimental value that can be calculated based on the retention time of an analyte on a system calibrated using compounds of known EPSA values.

2014年10月9日 · We have developed a supercritical fluid chromatography technique for peptides, termed EPSA, which is shown here to enable improved permeability design. Through assessing the exposed polarity of a...

2014年8月4日 · We have developed a supercritical fluid chromatography technique for peptides, termed EPSA, which is shown here to enable improved permeability design. Through assessing the exposed polarity of a peptide, this technique can be used as a permeability surrogate.

2017年2月6日 · EPSA is an experimental descriptor of molecular polarity obtained from chromatographic retention in supercritical fluid chromatography (SFC) systems, previously shown by Goetz et al. to correlate with passive permeability of cyclic peptides. The present study focuses on EPSA in relation to passive p …