2016年8月3日 · Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy. This effect is accompanied by increased protein …

MRF4通过抑制肌细胞增强因子2(myocyteenhancerfactorꎬ MEF2)的活性ꎬ负性调节成人骨骼肌生长ꎮ为了确定MRF4的

Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle …

2004年9月23日 · Here we show, using an allelic series of three Myf5 mutants that differentially affect the expression of the genetically linked Mrf4 gene, that skeletal muscle is present in the …

本文以生肌调节因子的分子结构为基础，对其在肌肉发育发生、控制卫星细胞功能和再生中的作用进行综述，以期为肌肉骨骼疾病的治疗提供新的思路。 引用本文: 徐齐宇, 王锋, 张全兵, 等. 生 …

2020年12月3日 · Our data show that Myf6 transcriptionally regulates a broad spectrum of myokines and muscle-secreted proteins in skeletal myofibers, including EGF. EGFR signaling …

2020年10月13日 · Among the four myogenic regulatory factors (MRFs), Myf6 is the only factor that is primarily expressed in fully differentiated muscle fibers (Figs 1 A and EV1 A). The …

2017年12月1日 · Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal …

Myogenic regulatory factors (MRF) are basic helix-loop-helix (bHLH) transcription factors that regulate myogenesis: MyoD, Myf5, myogenin, and MRF4. [1]These proteins contain a …

MRF4 is a member of the basic helix-loop-helix muscle regulatory factor family that also includes MyoD, myogenin, and Myf-5. Overexpression of MRF4 or the other muscle regulatory factors …