Objective: We aimed to investigate patterns of electroencephalography-correlated functional MRI (EEG-fMRI) and subtle structural abnormalities in patients with mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (MTLE-HS) or normal MRI (MTLE-NL).

2023年5月22日 · Mesial temporal lobe epilepsy (MTLE) is the most common form of focal epilepsy. This activity outlines the etiopathology, clinical presentation, diagnostic approach, and management of MTLE by an interprofessional team. Objectives: Outline the etiology and histopathological findings of mesial temporal lobe epilepsy.

In a recent study we observed significant amygdala enlargement (AE) in 14% of MTLE patients with MRI signs of hippocampal sclerosis. Areas of gray matter volume (GMV) increase could represent structural abnormalities related to the epileptogenic zone or …

This study used structural and diffusion magnetic resonance imaging (MRI) to evaluate thalamic connection density with distinct MTL subregions in terms of location and volume. Nineteen MTLE patients with unilateral hippocampal sclerosis (HS; 12 right; 10 female) were compared to 19 age-matched controls.

2014年6月5日 · We aimed to investigate patterns of electroencephalography‐correlated functional MRI (EEG‐fMRI) and subtle structural abnormalities in patients with mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (MTLE‐HS) or normal MRI (MTLE‐NL).

2021年5月3日 · In this work we investigated brain organization models specifically related to unilateral mesial temporal lobe epilepsy (mTLE) as a framework on which MRI functional and structural connectivity changes occur over time and space in these patients. In mTLE, seizures originate within one hippocampus and propagate across the brain (Engel, 2001).

2025年1月1日 · When tasked with lesion lateralization using high-resolution T1-weighted MRI for patients with mTLE, the proposed ML model trained on the top-10 ROIs demonstrated high test set accuracy (92.38 %) and AUROC (0.97), suggesting that it …

本文将综述与TLE生物标志物有关的定量MRI原理及其在TLE诊疗和癫痫网络研究中的应用进展，旨在协助TLE诊疗过程中精确定位致痫灶、评估病变程度，并制订个体化治疗方案。 T1与T2加权图像对比度源于质子固有弛豫特性的差异，即纵向弛豫时间和横向弛豫时间，其在一定温度和条件下保持不变 [11]。 与标准T1和T2加权成像相比，通过T1、T2 mapping直接测量组织的定量纵向弛豫时间（quantitative T1, qT1）以及定量横向弛豫时间（quantitative T2, qT2），具有更好地 …

2014年11月13日 · Results from selected volumetric and morphometric MRI studies that have addressed the relationship between preoperative brain structure and postoperative seizure outcome in patients with TLE. mTLE is indicated for samples with electrophysiological evidence of TLE and concomitant ipsilateral HS.

2017年3月7日 · We evaluate surgical outcomes of MRI-negative TLE, identify prognostic makers of postoperative seizure freedom, and discuss strategies for optimizing the selection of surgical candidates in this group.