2022年8月19日 · We developed a multiple reaction monitoring–mass spectrometry (MRM-MS) multimarker panel using 17 proteins from the sera of 398 patients. Area under the receiver operating characteristics curve (AUROC) values of this MRM-MS panel with and without α-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II …

2024年1月2日 · Here we design and validate multiple reaction monitoring mass spectrometry (MRM-MS) assays for quantitation of 2118 unique proteins in 20 murine tissues and organs.

靶向多反应监测质谱 (MRM-MS) 分析用于对 FFPE 组织中的生物标志物蛋白进行多重定量，与当前的“金标准”免疫组织化学 (IHC) 方法相比，提供了直接、更准确和更精确的定量。

Analysis of entire metabolic pathways using targeted MRM panel assays covering key pathways involved in the metabolism of cells and cancer. Over 265 available, absolute quantification targeted MRM assays spanning many of the key cellular metabolite pathways such as the glycolysis, pentose phosphate,…

Our immuno-MRM platform is uniquely able to capture the advantages of quantitative mass spectrometry. Utilizing target-specific affinity reagents and immuno-MRM proof-of-concept data, our platform enables highly flexible assays for oncology clinical trials.

The Paulovich Lab at Fred Hutchinson Cancer Research Center has developed and analytically validated a collection of targeted Mass Spectrometry-based proteomic assays (e.g. multiple reaction monitoring, MRM) spanning multiple cellular pathways.

2011年11月17日 · 质谱多反应监测 (multiple reaction monitoring, MRM)技术作为一种质谱检测的分析方法，具有特异性强、灵敏度高、准确度高、重现性好、线性动态范围宽、自动化高通量的突出优点，这些特质能够满足今天很多研究领域的迫切需要。 通过MRM技术进行实时的定量监测可以进行药代动力学研究、临床诊断、违禁药物检查、食品化妆品等工业质量控制、 环境检测 、农业植物学研究以及代谢组学和蛋白质组学Biomarker的发现等相关研究。 1. 质谱MRM技术的 …

2019年6月4日 · We developed and assessed robustness of a multiplexed MRM method to monitor peptides from 42 urinary proteins The majority of peptides are increased in LN urine compared to HC including lymphoid and inflammatory markers MRM panels can be used to interrogate disease biology for 10-100 protein biomarker candidates in one …

Uses high quality MRM-MS technology to simultaneously quantify up to 270 human or 125 mouse proteins from a single plasma sample! Comprehensive internal standards ensure accurate quantitation. The panel includes medium to low abundance proteins associated with cancer, CVD, and other diseases.

An emerging approach for multiplexed targeted proteomics involves bottom-up LC-MRM-MS, with stable isotope-labeled internal standard peptides, to accurately quantitate panels of putative disease biomarkers in biofluids.