The MRN complex contributes to the detection and repair of DNA damage, which is essential for genome stability and cell survival. This complex can sense damaged proteins through its NBS1 N-terminal domains and signal other molecules to trigger DDR.

2021年1月15日 · Upon detecting DNA damage, the MRN complex activates signaling molecules, such as the protein kinase ataxia-telangiectasia mutated (ATM), to trigger a broad DNA damage response, including cell cycle arrest.

2008年6月3日 · What is MRN? A complex of three proteins — Mre11, Rad50 and Nbs1 (also known as Nibrin or p95). It is essential for the viability of vertebrate, but not yeast, cells. The MRN complex is engaged in DNA metabolic events involving DNA double-strand ends.

Emerging data strongly support crucial roles for the MRN complex in preventing the genotoxic consequences of broken chromosomes. As a DSB-specific 'guardian of the genome', the MRN complex is thought to function in the suppression of transformation and malignancy.

In this review, we discuss the MRN complex’s role in DNA double-strand break repair, its interactions with other cancer predisposing genes, the variants that can be found within the three MRN complex genes, and the MRN complex’s potential as an anti-cancer therapeutic target.

The MRN complex is composed of dimers of the three proteins encoded by the MRE11, RAD50, and NBN genes. The complex participates in DNA double-stranded break repair, meiotic recombination, cell cycle checkpoints, and telomere maintenance.

2003年10月10日 · Here we show that functional MRN is required for ATM activation, and consequently for timely activation of ATM-mediated pathways. Collectively, these and previous results assign to components of the MRN complex roles upstream and downstream of ATM in the DNA damage response pathway and explain the clinical resemblance between A-T and A-TLD.

2008年10月3日 · The MRN complex is an assembly of two Mre11 subunits, two Rad50 subunits, and Nbs1 protein (Figure 1). This remarkably versatile protein assembly merges a number of activities that are essential for genome maintenance and duplication.

2025年3月6日 · The MRN complex, composed of MRE11, NBS1, and RAD50, is among the earliest elements involved in detecting DNA damage. Upon detecting DNA breaks, this complex triggers a cascade of signaling events that regulate both cell cycle arrest and DNA repair.

2023年4月5日 · The MRN complex consists of a symmetrical dimer assembled from two MRE11, RAD50 protomers (M 2 R 2) that are stabilized by NBN protein(s) . The entire complex is a dynamic molecular structure consisting of a globular DNA binding domain and two coiled-coil arms protruding 60 nm apart .