2004年1月1日 · In the LLC-PK 1 tubular renal cell line, a 15-day treatment with 25 μM rifampicin significantly increased the mRNA levels of P-glycoprotein, MRP1, MRP2, LRP and cytochrome P450 3A4 (CYP 3A4). Western blot analysis confirmed a moderate increase in the expression of P-glycoprotein and MRP2, but not MRP1 also at the protein level.

Abbreviations: AUC: area under the concentration-time curve; CYP: cytochrome P450; DDI: drug-drug interaction. 缩写: AUC: 浓度-时间曲线下面积; CYP: 细胞色素 P450; DDI: 药物-药物相互作用。 Table 4-1: Examples of in vitro substrates for transporters (9/26/2016) 表4-1: 转运蛋白体外基质的例子(9/26/2016)

2024年12月18日 · mrp2作为一种重要的药物转运蛋白，在药物转运、解毒和化学保护等方面发挥着重要作用。 本文详细解析了MRP2的结构与功能，探讨了其在药物处置中的重要作用，并讨论了相关疾病及其治疗中的应用前景。

CYP, cytochrome P450; MRP2, multidrug resistance-associated protein 2. Population pharmacokinetics of tacrolimus. To understand the relative impacts of these polymorphisms on the pharmacokinetics of tacrolimus, population pharmacokinetic analysis was carried out. The pharmacokinetics of tacrolimus was best described using a 2-compartment model ...

Some of the flavonoids caused weak inhibition of OATP1A2 and MRP2. However, most of the compounds tested proved to be strong inhibitors of OATP1B1, OATP1B3, OATP2B1, and BCRP. Our data demonstrate that not only quercetin but some of its conjugates, can also interact with CYP enzymes and drug transporters.

Genetic polymorphisms in CYP3A4 and CYP3A5 genes as well as the genes of efflux transporters including P-gp (ABCB1), multidrug resistance-associated protein (MRP2/ ABCC2) and breast cancer resistance protein (BCRP/ ABCG2) were genotyped.

2016年10月14日 · The results suggest that P-gp, MRP2 and CYP3A4 play important roles in prohibiting the enteral absorption of OCT, particularly under a PH environment. Moreover, inhibitors of P-gp, MRP2 and CYP3A4 decrease the first-pass effects of OCT and effectively reduce PVP under PH conditions.

2021年1月6日 · mrp2 的转运过程是排泄内源性和外源性毒素的重要过程，是肝脏的重要解毒功能之一。在发生胆汁淤积时，肝细胞膜转运蛋白mrp2 表达会降低，胆红素和毒素不能进胆管排除，就会造成肝细胞损伤和体外肝细胞性黄疸。

2004年1月1日 · In the LLC-PK (1) tubular renal cell line, a 15-day treatment with 25 microM rifampicin significantly increased the mRNA levels of P-glycoprotein, MRP1, MRP2, LRP and cytochrome P450 3A4 (CYP 3A4). Western blot analysis confirmed a moderate increase in the expression of P-glycoprotein and MRP2, but not MRP1 also at the protein level.

2004年1月1日 · Multidrug resistance protein 2 (MRP2, ABCC2) is a drug efflux pump belonging to the ATP-binding cassette (ABC) transporter superfamily. MRP2 is present predominantly at the biliary pole of hepatocytes and is also expressed in the kidney and intestine.