2023年11月29日 · In this study, the global regulator SarA was used as a target to virtually screen natural active monomers. SarA inhibitor quercetin (QEN) was assessed. Molecular docking and kinetic simulation showed that QEN was stably bound to the formation site of SarA dimer. Spectral analysis verified that QEN was bound to SarA and changed its conformation.

2021年2月15日 · In specific, we correlated the efficacy of structurally diversified pyrazole analogs against MRSA and discussed different angles of structure-activity relationship (SAR). The current survey highlights pyrazole hybrids’ present scenario on MRSA studies, covering articles published from 2011 to 2020.

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, ...

2024年4月1日 · The current review discusses the SAR of the antibacterial activity of sulfur (S Ⅵ) containing heterocyclic scaffolds majorly azole moieties against diverse MRSA strains. We anticipate that the present review will offer a platform to chemical biology researchers with thorough information to assist them for further exploration of sulfur (S Ⅵ ...

The most dangerous feature is the fast emergence of MRSA resistance to all recognized antibiotics, including vancomycin. The creation of novel, effective, and non-toxic drug candidates to combat MRSA isolates is urgently required. Fluorine containing small molecules have taken a centre stage in the field of drug development.

2023年11月5日 · Methicillin-resistant Staphylococcus aureus (MRSA) is a common and virulent bacterium in clinical practice. Numerous researchers have focused on developing new candidate drugs that are effective, less toxic, and can overcome MRSA resistance.

Benzimdazoles act as DNA binding agents, enzyme inhibitors, anti-biofilm agents and showed synergistic effect with available antibiotics to achieve antibacterial activity against MRSA. This cumulative figures would help to design new benzimidazole-based MRSA growth inhibitors.

Meticillinresistenta Staphylococcus aureus (MRSA) är stammar av stafylokocker som är resistenta mot penicillinpreparat. Infektioner med MRSA kan därför vara svåra att behandla. MRSA är ett stort vårdhygieniskt problem runt om i världen. Vad …

MRSA står för Meticillinresistent Staphylococcus aureus. Det betyder gula stafylokocker som är resistenta mot meticillin. Meticillin är en typ av antibiotika som brukar användas vid infektioner orsakade av stafylokocker. Resistent är ett annat ord för motståndskraftig. Vad är MRSA? Du kan ha MRSA på kroppen utan att ha besvär.

2023年4月2日 · MRSA infection is one of the leading causes of hospital-acquired infections and is commonly associated with significant morbidity, mortality, length of stay, and cost burden. MRSA infections can be further divided into hospital-associated (HA-MRSA) infections and community-associated (CA-MRSA) infections.