We have provided a brief overview of Diosmin, its pharmacology, major biological properties, such as anti-cancer, anti-diabetic, antibacterial, anticardiovascular, liver protection, and neuroprotection, therapeutic approach, potential Diosmin targets, and pathways that are known to be associated with it.

We describe the development and validation of a liquid chromatography–mass spectrometry (LC-MS/MS) method to determine diosmetin in plasma, upon enzymatic degradation with diosmetin-free glucuronidase and sulfatase.

2010年3月11日 · A sensitive, accurate and precise bioanalytical method involving a simple liquid–liquid extraction of plasma samples and LC–MS/MS determination of diosmin and diosmetin was developed and validated to meet the requirements of …

The primary objective was to compare the pharmacokinetic profile of two oral tablets containing a formulated diosmin complex (T) and unformulated micronized diosmin (R), through plasma concentration of diosmetin, as the main metabolic by-product of ingested diosmin, in …

Diosmin is a bioflavonoid isolated from various plants or synthesized from [hesperidin]. It is used for the improvement of capillary fragility or venous insufficiency, including chronic venous insufficiency (CVI) and hemorrhoids. Diosmin is widely available over-the-counter and demonstrates a favourable a favorable safety profile.

Diosmin is a flavonoid often administered in the treatment of chronic venous insufficiency, hemorrhoids, and related affections. Diosmin is rapidly hydrolized in the intestine to its aglicone,...

Pharmacokinetic studies of diosmin were performed after an oral administration to healthy volunteers. Diosmin and its aglycone, diosmetin, were determined by HPLC and LC-MS techniques. At least, at the level of sensitivity of our method, no parent compound was present in the plasma but only its agly …

2010年3月11日 · Diosmin is hydrolyzed by enzymes of intestinal micro flora before absorption of its aglycone diosmetin. A specific, sensitive, precise, accurate and robust HPLC assay for the simultaneous determination of diosmin and diosmetin in …

2024年6月1日 · Diosmin (9) protects against mitochondrial damage and lowers cardiac mitochondrial oxidative stress in rats with isoproterenol-induced myocardial infarction because of its antioxidant properties and negative inotropic traits. It is also supported by studies conducted with transmission electron microscopy.

2013年2月14日 · The newly developed RP–LC method for quantitative determination of diosmin-related substances was found to be precise, accurate, robust and specific. It has been successfully employed for the quality evaluation of different sources of raw material and generic formulations of diosmin.