2024年5月2日 · Leveraging outstanding features such as high biocompatibility, low immunogenicity, superior biological barrier penetration, and extended circulating half-life, MSC-EVs serve as potent carriers...

2020年3月12日 · Studies show that EV from MSCs (MSC-EV) have regenerative and anti-inflammatory properties. The use of MSC-EV, as an alternative to MSCs, confers several advantages, such as higher safety profile, lower immunogenicity, and the ability to cross biological barriers, and avoids complications that arise from stem cell-induced ectopic tumor ...

2022年7月4日 · We describe some characteristics of MSC-EVs, and discuss their role in immune regulation and regeneration, with emphasis on the molecular mechanism and application of MSC-EVs in the treatment...

2024年2月16日 · There is a growing body of evidence suggesting that the immunomodulatory and rejuvenative properties of mesenchymal stem cells (MSCs) are mediated through the paracrine effects of the extracellular...

近年来许多研究表明，间充质干细胞（mesenchymal stem cell, MSC）对于SI-ALI有潜在治疗作用 [ 7 , 8 , 9 ]，其中部分作用被认为是其分泌的细胞外囊泡（extracellular vesicle, EV）所带来的。

2023年10月1日 · MSC-EV-treated defects showed superior pain tolerance level and improved histological scores than the MSC-treated defects (Zavatti et al., 2020). Evidence suggests that MSC-EVs display angiogenic, immune-modulatory, and therapeutic properties similar to MSCs, thereby accounting for much of the paracrine effects of MSCs ( El Andaloussi et al ...

2022年3月1日 · MSC-EV are a potential therapy through immunomodulation in multiple disease models. Common MSC-EV mechanisms of action affect the NFκB and Stat3 pathways. A variety of miRNA and EV-associated proteins account for foremost MSC-EV effects. The bioengineering of MSC-EVs is a feasible option to enhance MSC-EV function.

2023年2月28日 · Studies have confirmed the therapeutic value of mesenchymal stem cell-derived EVs (MSC-EVs) for treating infectious diseases to eliminate the pathogen, modulate the resistance, and restore tissue damage in infectious diseases.

We provide an overview of the major characteristics of MSC-EVs and summarize the recent advances of MSC-EV-based therapy for hyperglycemia-induced tissue damage with an emphasis on MSC-EV-mediated delivery of functional components.

2020年9月29日 · MSC-derived extracellular vesicles (MSC-EVs) are able to duplicate the effects of their parental cells by transferring functional proteins and genetic materials to recipient cells without cell-to-cell contact. MSC-EVs also target macrophages, which play an essential role in innate immunity, adaptive immunity, and homeostasis.