2016年12月6日 · Bone-marrow derived mesenchymal stromal cells (MSCs) have potent immunomodulatory and tissue reparative properties, which may be beneficial in the...

2022年3月21日 · A variety of growth factors have been identified among the secretion profile of MSCs, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor …

2020年5月14日 · In this study, we prove the key role played by HGF in the functional recovery stimulated by the MSC-conditioned medium (MSC-CM). Bone marrow mesenchymal stem …

Hepatocyte growth factor (HGF) has important roles in the cell and tissue repairment and regeneration. Here we investigated the enhanced effects of HGF-modified MSCs on I/R …

2021年5月23日 · VEGF培养MSC，可以降低了MSC长期培养导致的p16INK，p21和p19ARF的表达，通过增加Akt磷酸化，促进Bcl-xL表达和降低Bax的表达，提高了抗凋亡能力；与单独注 …

2020年2月28日 · We hypothesized that HGF is a key factor in the MSC-mediated regulation of the T helper 17 (Th17) cell/regulatory T (Treg) cell balance. We investigated the effects of MSCs …

2016年8月24日 · Accumulative evidence demonstrated that mesenchymal stem cell (MSC) engraftment could protect tissue injury from ischemia/reperfusion (I/R). Hepatocyte growth …

In this context, we show that short-term exposure of mesenchymal stem cells (MSCs) to HGF can induce the activation of its cognate Met receptor and the downstream effectors ERK1/2, …

Functional assays identify a critical role for Hepatocyte Growth Factor (HGF) and its primary receptor cMet in MSCs stimulated recovery in EAE, neural cell development and remyelination.

肝细胞生长因子 (HGF)在小鼠异基因骨髓移植模型中具有免疫抑制和修复损伤作用，从多环节减轻GVHD的发生，同时保留GVL效应。 为明确MSC和HGF基因两者联合是否具有免疫协同效 …