The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS), a critical factor in the innate immune response pathway, is essential for checkpoint blockade immunotherapy in animal …

2024年4月9日 · The cGAS-STING DNA-sensing pathway has emerged as a central mediator of host defense, a cause of numerous human immune diseases, a contributor to fundamental …

2021年1月11日 · While neoantigens result from the hypermutable nature of dMMR, it is unknown how dMMR activates the cGAS-STING pathway. We show here that loss of the MutLα subunit …

2020年12月19日 · MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway. 研究团队发现错配修复缺陷 （dMMR） 肿瘤因为缺失MLH1基因从 …

2021年1月11日 · To determine whether dMMR-mediated immunotherapy responsiveness occurs via activation of the cGAS-STING pathway, we generated Mlh1-knockout (Mlh1 −/−) and Mlh1 …

MLH1 deficiency triggers activation of the cGAS-STING pathway. Indeed, we have recently shown that tumor cells defective in MLH1 accumulate cytosolic DNA to activate the cGAS …

2021年1月11日 · Using tumor models defective in the MMR gene Mlh1 (dMLH1), we show that dMLH1 tumor cells accumulate cytosolic DNA and produce IFN-β in a cGAS-STING …

2023年6月2日 · Here, our study reports that methionine deprivation enhances cGAS activity by blocking its methylation, which is catalyzed by methyltransferase SUV39H1. We further show …

在这篇综述中，作者探讨了cGAS的病理和保护功能，并总结了两个最新的进展，提供了对cGAS-STING通路调控的意外见解。 第一个是关于cGAS与染色质紧密连接的新见解，挑战了“细胞 …

突变亨廷顿蛋白诱导 MLH1 降解、DNA 过度切除和 cGAS-STING 依赖性细胞凋亡 Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4) Pub Date : 2024 …