2023年5月22日 · Mesial temporal lobe epilepsy (MTLE) is the most common form of focal epilepsy. This activity outlines the etiopathology, clinical presentation, diagnostic approach, and management of MTLE by an interprofessional team.

In mTLE, scalp EEG in most instances can lateralize and localize the seizure focus. Other than epileptiform discharges, abnormal lateralized EEG patterns such as TIRDA could be quite specific for the ipsilateral seizure onset.

The syndrome of mesial temporal lobe epilepsy (MTLE) is a well-defined clinical entity that responds to surgical treatment in a considerable number of patients. Although it has been subjected to intensive clinical research, few investigators have published the ictal scalp EEG findings and looked for …

2025年3月1日 · We investigated EEG features differentiating clinical seizures (CSs) from subclinical seizures (SCSs) to explore the mechanisms underlying the generation of ictal behavior in mesial temporal lobe epilepsy (mTLE).

2022年1月1日 · Hippocampal sclerosis (HS) is the most common etiology found in patients with drug-resistant mesial temporal lobe epilepsy (MTLE) (Fig. 27.1). About 25% of patients with focal epilepsy, 36%–39% with drug-resistant focal epilepsy, and up to 70% with drug-resistant TLE had radiological or histopathological findings of HS ( Semah et al., 1998 ...

2008年9月1日 · Interictal EEG activity in mesial temporal lobe (MTL) structures (hippocampus, entorhinal cortex and amygdala) was obtained from intracerebral recordings performed in 21 patients with drug-resistant mesial temporal lobe epilepsy (MTLE group).

In this work, visually-normal EEG signals from 26 patients with MTLE and 26 healthy controls (HC) were analyzed with the aim of compared spectral parameters between two groups of subjects to identify differences.

Objective: To compare quantitative spectral parameters of visually-normal EEG between Mesial Temporal Lobe Epilepsy (MTLE) patients and healthy controls (HC). Method: We enrolled 26 MTLE patients and 26 HC. From each recording we calculated total power of all frequency bands and determined alpha-theta (ATR) and alpha-delta (ADR) power ratios in ...

SynapCell’s MTLE model uses advanced EEG biomarkers to monitor non-convulsive seizures, mirroring human epilepsy. This innovative approach, developed through extensive R&D, offers drug discoverers crucial insights when assessing molecule efficacy at the preclinical stage, to accelerate the development of epilepsy treatments.

A proper MRI investigation of patients with focal epilepsy requires the use of specific protocols, selected based on identification of the region of onset by clinical and EEG findings. For practical purposes, focal epilepsy can be divided into mesial temporal-lobe epilepsy (MTLE) and neocortical epilepsy.