MYC、BCL-2和/BCL-6重排高级别B细胞淋巴瘤的诊断与治疗
MYC位于8q24，在淋巴瘤中表达时促进细胞增殖、诱导基因组不稳定、增加转录；BCL2位于18q21，与其它原癌基因协同，主要是MYC，加速淋巴瘤进展，与化疗耐药有关。 BCL-6在正 …
Characteristics and Clinical Value of MYC, BCL2, and BCL6 …
These results indicated that targeted NGS is a powerful clinical diagnostics tool for comprehensive MYC, BCL2, and BCL6 rearrangement detection. Compared to FISH, it has …
伴MYC、BCL2和（或）BCL6重排的高级别B细胞淋巴瘤在弥漫大B …
双重打击淋巴瘤（Double-hit lymphoma，DHL）是弥漫大B细胞淋巴瘤（DLBCL）近年来的研究热点，DHL指具有MYC基因断裂伴其他重现性染色体断裂的淋巴瘤，以伴BCL2或BCL6基因断 …
MYC status in concert with BCL2 and BCL6 expression predicts outcome in ...
2013年3月21日 · While different results have been published regarding the impact of BCL2 and BCL6 breaks on prognosis in DLBCL, 6-12 MYC translocations confer a worse prognosis in …
Non-IG::MYC in diffuse large B-cell lymphoma confers variable …
2024年1月6日 · MYC translocation occurs in 8–14% of diffuse large B-cell lymphoma (DLBCL), and may concur with BCL2 and/or BCL6 translocation, known as double-hit (DH) or triple-hit …
High Grade B-Cell Lymphoma with MYC/BCL6-Rearrangements …
2024年11月5日 · Introduction: High grade B-cell lymphomas with MYC, BCL2 and/or BCL6 rearrangements (R) are a group of aggressive lymphomas with poor prognosis when treated …
Pathology Outlines - BCL6
6 天之前 · The tumor cells are immunoreactive for CD20, CD10, BCL6 and BCL2 and negative for MUM1, MYC and CD30, which confirms the diagnosis. The Ki67 proliferation rate is …
MYC to BCL6 State-Transitions Determine Cell Size and Metabolic ...
2023年11月2日 · MYC is involved in biomass accumulation and provides fuel for cell division, while BCL6 confers a quiescent phenotype to cells and protects B cells from DNA damage …
High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 ... - PubMed
2018年5月3日 · High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) is a newly defined entity in the latest World Health Organization Classification. …
Limited stage high grade B-cell lymphoma with MYC, BCL2 and/or BCL6 …
2024年10月14日 · High-grade B-cell lymphoma with MYC, BCL2 and/or BCL6 rearrangements (HGBCL-DH/TH) is a group of aggressive lymphomas that are associated with poor outcomes …
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