2024年2月1日 · We show that the majority of MYC-SL nucleocytoplasmic transport genes are upregulated in MYC high murine HCC and are associated with poor survival in HCC patients. Inhibiting Exportin-1 (XPO1)...

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.

We propose that the cleavage of Myc by calpain abrogates the transcriptional inhibition of differentiation by full-length Myc and generates Myc-nick, a driver of cytoplasmic reorganization and differentiation.

2023年10月24日 · MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier that regulates almost every physiological process in a cell including cell cycle, proliferation, metabolism, differentiation, and apoptosis. MYC interacts with several cofactors, chromatin modifiers, and regulators to direct gene expression.

2010年8月6日 · Here we report the identification of Myc-nick, a cytoplasmic form of Myc generated by calpain-dependent proteolysis at lysine 298 of full-length Myc. Myc-nick retains conserved Myc box regions but lacks nuclear localization signals and the bHLHZ domain essential for heterodimerization with Max and DNA binding.

The Myc-estrogen receptor (Myc-ER) fusion protein system has become a standard for establishing the direct regulation of a candidate target gene by c-Myc . In this system, the Myc-ER fusion protein is retained in the cytoplasm via chaperone proteins.

These findings suggest that, during the 12-O-tetradecanoylphorbol-13-acetate-induced differentiation and loss of proliferation of ML-1 cells, c-myc protein is regulated through alterations that affect its cytoplasmic/nuclear distribution rather than its total cellular content.

2025年2月7日 · MYC mediates its functions as a transcription factor that controls the expression of thousands of genes involved in a multitude of cancer hallmarks: either cancer cell-intrinsic functions such as...

2017年6月13日 · We observed positive staining of C-MYC either in the nucleus or cytoplasm or in both subcellular locations. There were significant differences in cytoplasmic C-MYC expression, Ki-67 proliferative index of tumor cells, and CD8 positive tumor infiltrating lymphocytes (CD8+TIL) among three risk groups ( P = 0.000, P = 0.037 and P =0.020 ...

2025年2月19日 · MYC is among the most infamous oncogenes in cancer. A notable feature that distinguishes it from other common oncogenes is that its deregulation is not usually due to direct mutation, but instead...