2008年3月17日 · We now show that Myc is required to allow the interaction of the E2F1 protein with the E2F gene promoters. As such, Myc thus provides a link between the development of a growth-competent...

细胞周期蛋白依赖性激酶 (CDK)-RB-E2F 调控轴组成了驱动细胞周期进程、决定基因组复制的时间和准确性、并确保遗传物质准确传递的核心转录机制。 该调控轴的最终效应子是编码转录激活因子和抑制因子的8个不同 E2F 基因家族的成员（E2F1-8）。 E2F 转录活性在整个细胞周期中通过转录和翻译调控、翻译后修饰、蛋白质降解、与辅因子的结合和亚细胞定位等过程受到严格调控。 该调控轴的一个或多个关键成分 (CDKs, cyclins, CDK inhibitors and the RB family of proteins) …

2015年7月20日 · Here, we investigated how two critical proliferative pathways, Myc and E2f, are integrated to control cell cycles in normal and Rb -deficient cells using a murine intestinal model. We show that...

2000年10月17日 · Using primary mouse embryo fibroblasts deleted for individual E2F genes, we now show that Myc-induced S phase and apoptosis requires distinct E2F activities. The ability of Myc to induce S phase is impaired in the absence of either E2F2 or E2F3 but not E2F1 or E2F4.

2023年11月28日 · In this study, we show that Rb-protein reduction and c-Myc, induced by mitogenic or hormone signaling, sequentially drive E2F transcriptional activity. This facilitates the development of persisters and ultimately CDK4/6i resistance in breast cancer.

2018年7月25日 · Here, we present emerging data supporting novel roles of NRF1 in cancer development and progression through its interplay with the transcription factors E2F4 and MYC. To identify common human NRF1, E2F4 and MYC target genes, we analyzed the Encyclopedia of DNA Elements (ENCODE) NRF1 ChIP-Seq data.

Candidate molecules that mediate c-Myc- and E2F1-enhanced apoptosis include p14/p19ARF, ornithine decarboxylase and lactate dehydrogenase-A (for c-Myc) as well as p14/p19ARF, p73, Apaf-1 and caspase-3 (for E2F1). c-Myc also activates the CD95/Fas-FADD-mediated death signal. c-Myc and E2F1 inhibit NF-kappaB activities induced by TNFalpha or ...

2015年7月31日 · Activator E2Fs and Myc cooperate as master regulators of proliferation. A new study sheds light on one of the fundamental questions in cancer biology: how do oncogenic changes, such as...

2002年5月10日 · Although E2F and Myc are firmly established as key regulators of cellular proliferation, the new work points to an additional, perhaps crucial, role for E2F in maintaining cells in the quiescent G 0 phase of the cell cycle. It is well established that E2F regulates early cell cycle transitions, from G 0 into G 1 and S phase (4).

2023年6月8日 · Here, we show that CDK7 expression positively correlates with E2F and MYC transcriptional programs in cells from patients with multiple myeloma (MM); its selective targeting counteracts E2F activity via perturbation of the cyclin-dependent kinases/Rb axis and impairs MYC-regulated metabolic gene signatures translating into defects in glycolysis ...