2019年11月20日 · MYC, a proto-oncogene located on chromosome 8q24, is the most commonly altered oncogene in human cancer 1, 2. The encoded protein (MYC) is a multifunctional, nuclear phosphoprotein that plays a...

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.

myc基因是目前研究最多的一类核蛋白类癌基因，包括c—myc、n—myc、l—myc、r—myc 4种。 C-MYC 原癌基因是最常见的活化原癌基因之一，C-MYC参与调控的癌症占人类所患癌症的20%左右，受C-MYC原癌基因影响致死的癌症患者每年可达几十万。

2024年12月25日 · MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYCN include Feingold Syndrome 1 and Megalencephaly-Polydactyly Syndrome. Among its related pathways are Signaling by TGFBR3 and Signaling by TGFB family members.

Areas covered: This article summarizes the genomic and transcriptomic studies that compile evidence for (i) MYC, MYCN, and MYCL amplification and overexpression in lung cancer patients, and (ii) their prognostic significance. We collected the most recent literature regarding the development of Myc inhibitors where the emphasis is on those ...

2019年11月20日 · MYC is the most altered oncogene in human cancer, and belongs to a large family of genes, including MYCN and MYCL. Recently, while assessing the degree of correlation between MYC gene rearrangement and MYC protein expression in aggressive B-cell lymphomas, we observed few Burkitt lymphoma (BL) cases …

背景和目标 MYC，也称为致癌重编程因子，是一种维持诱导多能干细胞 (iPSC) 的多功能转录因子。 尽管 MYC 在各种癌症中经常上调并与不良预后相关，但 MYC 在肺腺癌中下调并与良好预后相关。 MYC 和另外两个 MYC 家族基因 MYCN 和 MYCL 具有相似的结构，并且可能有助于体外和体内的致瘤转化。 方法和结果 我们系统地调查了 MYC 家族基因是否作为各种人类癌症的预后因素。 我们首先使用 Oncomine 和癌症基因组图谱 (TCGA) 数据库评估了各种癌症中 MYC 家族基因 …

2021年3月10日 · Myc protein orchestrates diverse physiological processes, including cell proliferation, differentiation, survival, and apoptosis. Myc modulates about 15% of the global transcriptome, and...

2021年2月3日 · MYCN, a member of MYC proto-oncogene family, encodes a basic helix-loop-helix transcription factor N-MYC. Abnormal expression of N-MYC is correlated with high-risk cancers and poor prognosis. Initially identified as an amplified oncogene in neuroblastoma in 1983, the oncogenic effect of N-MYC is expanded to multiple neuronal and nonneuronal tumors.

myc基因是较早发现的一组 癌基因，包括C - myc，N -myc，L - myc ，分别定位于8号染色体， 2号染色体 和 1号染色体。 结构上由不编码 蛋白质 的第1 外显子 和编码蛋白质的第2、3外显子构成，与之同源的 病毒癌基因 存在于MC29及其它一些具有高度 致癌性 的猿逆转录病毒中。 myc基因高水平表达时可转化 啮齿类 成纤维细胞。 myc基因首次在Burkitt淋巴瘤中发现，可通过染色体易位而活化，最常见的是通过8号染色体与 14号染色体 间易位，使得8号染色体上的myc基因 …