Canonical WNT signaling-dependent gating of MYC requires a
2022年1月11日 · Abnormal WNT signaling increases MYC expression in colon cancer cells in part via oncogenic super-enhancer- (OSE)-mediated gating of the active MYC to the nuclear pore …
经典信号通路总结——Wnt信号通路 - 知乎 - 知乎专栏
胞浆中稳定积累的β-Catenin进入细胞核后结合LEF/TCF转录因子家族，启动下游靶基因 (如c-myc、Cyclin D1等) 的转录。 Wnt/β-catenin 途径调控着干细胞的多能分化、器官的发育和再 …
Wnt/β-catenin signaling pathway upregulates c-Myc expression …
C-myc downregulation inhibited P19 cell proliferation caused by activation of Wnt/β-catenin signaling and induced P19 cell differentiation. In conclusion, activation of the Wnt/β-catenin …
Wnt/β-catenin signalling: function, biological mechanisms, …
2022年1月3日 · Wnt signalling plays an important role in the self-renewal of some tissues in mammals. For example, the Wnt signalling pathway is related to the development and renewal …
WNT signaling and AHCTF1 promote oncogenic MYC expression …
2019年11月29日 · WNT signaling activates MYC expression in cancer cells. Here we report that this involves an oncogenic super-enhancer-mediated tethering of active MYC alleles to nuclear …
MYC hyperactivates WNT signaling in APC/CTNNB1-mutated …
Myc enhances Wnt signaling by enabling the miR-92a/DKK3 axis. Since overexpressed Myc down-regulates DKK3, which acts as a Wnt signaling inhibitor, we hypothesized that in …
Regulation of MYC gene expression by aberrant Wnt/β-catenin …
Deregulated expression of the c-MYC proto-oncogene (MYC) by aberrant Wnt/β-catenin signaling drives colorectal carcinogenesis. In this review, we discuss the current literature pertaining to …
Induction of LEF1 by MYC activates the WNT pathway and …
MYC regulates the levels of numerous WNT-related genes, including the β-catenin co-transcription factor LEF1. MYC activates the transcription of LEF1 and is required for LEF1 …
MYC Mediates mRNA Cap Methylation of Canonical Wnt/β …
Mechanistic evidence indicates that MYC promotes recruitment of RNA methyltransferase (RNMT) to Wnt signaling gene promoters by enhancing phosphorylation of serine 5 on the …
经典 Wnt/β-catenin 通路的激活赋予 c-Myc/E2F1 转基因肝癌小鼠 …
在这里，我们研究了负责野生型 β-连环蛋白核易位的机制，并解决了 Wnt 通路在 c-Myc/E2F1 肝癌发生中的潜在贡献。方法通过微卫星和蛋白质印迹分析确定Wnt通路成员的状态。结果 无论是 …
- 某些结果已被删除